Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Comparison of paired-pulse facilitation of AMPA and NMDA synaptic currentsin the lateral amygdala
Autore:
Zinebi, F; Russell, RT; McKernan, M; Shinnick-Gallagher, P;
Indirizzi:
Univ Texas, Med Branch, Dept Pharmacol & Toxicol, Galveston, TX 77555 USA Univ Texas Galveston TX USA 77555 acol & Toxicol, Galveston, TX 77555 USA Johns Hopkins Univ, Baltimore, MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 s Univ, Baltimore, MD 21205 USA Wake Forest Univ, Baptist Med Ctr, Dept Radiol, Winston Salem, NC 27157 USA Wake Forest Univ Winston Salem NC USA 27157 , Winston Salem, NC 27157 USA
Titolo Testata:
SYNAPSE
fascicolo: 2, volume: 42, anno: 2001,
pagine: 115 - 127
SICI:
0887-4476(200111)42:2<115:COPFOA>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; RAT HIPPOCAMPAL SLICES; EXCITATORY POSTSYNAPTIC POTENTIALS; GLUTAMATE-RECEPTOR DESENSITIZATION; MEDIAL GENICULATE-BODY; PROTEIN-KINASE-C; PATCH-CLAMP; BASOLATERAL AMYGDALA; PYRAMIDAL CELLS; GRANULE CELLS;
Keywords:
fear-conditioning; learning; memory; plasticity; fear; short-term plasticity; PPF; short-term plasticity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
74
Recensione:
Indirizzi per estratti:
Indirizzo: Shinnick-Gallagher, P Univ Texas, Med Branch, Dept Pharmacol & Toxicol, Galveston, TX 77555 USA Univ Texas Galveston TX USA 77555 ton, TX 77555 USA
Citazione:
F. Zinebi et al., "Comparison of paired-pulse facilitation of AMPA and NMDA synaptic currentsin the lateral amygdala", SYNAPSE, 42(2), 2001, pp. 115-127

Abstract

Stimulating thalamic fibers exiting from the internal capsule evokes a glutamatergic excitatory postsynaptic current (EPSC) recorded in vitro with patch electrodes in neurons of the rat lateral amygdala (LA). The purpose of this study is to compare paired-pulse facilitation (PPF), a form of short-term synaptic plasticity, of AMPA and NMDA receptor-mediated EPSCs. Analysisof PPF at this synapse is important since, in fear-conditioned animals, PPF reflects an enhanced transmitter release but the amplitude of only AMPA EPSCs is facilitated. PPF magnitude of the composite EPSC is a result of both AMPA and NMDA receptor activation; however, the characteristics of AMPA and NMDA PPF are dissimilar. Specifically, the NMDA EPSC shows greater PPF (NMDA PPF) than does the AMPA EPSC whether measuring the NMDA PPF magnitude in an AMPA antagonist/Mg2+-free solution or by subtracting the AMPA EPSC from the composite EPSC in normal Mg2+. Presynaptic NMDA receptors neither influence AMPA PPF nor account for the difference between the NMDA and AMPA PPF. Another difference was that removal of inhibitory tone enhanced AMPA PPF, while it had mixed effects on NMDA PPF. Furthermore, AMPA PPF was independent of stimulus intensity and postsynaptic voltage, unlike the NMDA PPF. Another dissimilarity was that the amplitudes of pairs of AMPA EPSCs were not correlated, suggesting presynaptic mechanisms. In contrast, NMDA PPF wasdependent on stimulus intensity and postsynaptic voltage and the amplitudes of paired NMDA EPSCs had a positive correlation, suggesting a postsynaptic influence. Both AMPA and NMDA PPF were influenced by GABA inhibition and this could be a factor in the magnitude disparity. These data show that AMPA and NMDA PPF have different characteristics and contribute to the composite PPF in the thalamic to lateral amygdala pathway. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 12:36:30