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Titolo:
Effects of bilateral olfactory bulbectomy on N-methyl-D-aspartate receptorfunction: Autoradiographic and behavioral studies in the rat
Autore:
Robichaud, M; Beauchemin, V; Lavoie, N; Dennis, T; Debonnel, G;
Indirizzi:
McGill Univ, Dept Psychiat, Montreal, PQ H3A 1A1, Canada McGill Univ Montreal PQ Canada H3A 1A1 hiat, Montreal, PQ H3A 1A1, Canada
Titolo Testata:
SYNAPSE
fascicolo: 2, volume: 42, anno: 2001,
pagine: 95 - 103
SICI:
0887-4476(200111)42:2<95:EOBOBO>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBELLAR GRANULE NEURONS; NMDA RECEPTORS; BENZODIAZEPINE RECEPTORS; GLUTAMATE RECEPTORS; FRONTAL-CORTEX; H-3 MK-801; GABA-A; BRAIN; MODULATION; DEPRESSION;
Keywords:
depression; MK-801; dizocilpine; animal model; NMDA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Debonnel, G McGill Univ, Dept Psychiat, 1033 Pine Ave W, Montreal, PQ H3A 1A1, Canada McGill Univ 1033 Pine Ave W Montreal PQ Canada H3A 1A1 Canada
Citazione:
M. Robichaud et al., "Effects of bilateral olfactory bulbectomy on N-methyl-D-aspartate receptorfunction: Autoradiographic and behavioral studies in the rat", SYNAPSE, 42(2), 2001, pp. 95-103

Abstract

Rat bilateral olfactory bulbectomy (OBX) serves as a useful model in the study of depression and the mechanisms of action of antidepressant treatments. Considering the evidence of NMDA receptors involvement in depression, the present study was undertaken in order to investigate the time-course effects of OBX on the NMDA receptor function. Following bilateral olfactory bulbectomy, rats display an increase in locomotor activity and changes in other types of behavior in a novel environment. Autoradiographic experiments using the noncompetitive NMDA antagonist [I-125]-iodo-MK-801 as the labeling agent showed that this increase in behavioral activities corresponds to a decrease in [I-125]-iodo-MK-801 binding in a number of brain regions. In most regions, this reduction reached significance by the third week following OBX. However, in some cortical areas-a nucleus of the thalamus (AV) and oneof the amygdala (LA)-this reduction was already significant in the first or second week following OBX and lasted throughout the 4 weeks of the study. We also compared the behavioral modifications induced by a challenge injection of MK-801 (0.2 mg/kg i.p.) in OBX and sham-operated rats. This challenge is known to induce hyperlocomotion and a number of stereotypies in naiverats. These effects were drastically reduced in OBX as compared to sham-operated rats. These data are consistent with the above-mentioned decrease incerebral binding of MK-801 to NMDA receptors. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 09:46:15