Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Chemoprevention of basal cell carcinomas in the ptc1(+/-) mouse - Green and black tea
Autore:
Hebert, JL; Khugyani, F; Athar, M; Kopelovich, L; Epstein, EH; Aszterbaum, M;
Indirizzi:
Univ Calif San Francisco, Dept Dermatol, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Columbia Univ, Dept Dermatol, New York, NY 10027 USA Columbia Univ New York NY USA 10027 Dept Dermatol, New York, NY 10027 USA NCI, Div Canc Prevent, Bethesda, MD 20892 USA NCI Bethesda MD USA 20892NCI, Div Canc Prevent, Bethesda, MD 20892 USA
Titolo Testata:
SKIN PHARMACOLOGY AND APPLIED SKIN PHYSIOLOGY
fascicolo: 6, volume: 14, anno: 2001,
pagine: 358 - 362
SICI:
1422-2868(200111/12)14:6<358:COBCCI>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
ULTRAVIOLET-B LIGHT; HAIRLESS MICE; SKH-1 MICE; SKIN-CANCER; POLYPHENOLS; PREVENTION; PROTECTION; GROWTH; PHOTOCARCINOGENESIS; CARCINOGENESIS;
Keywords:
basal cell carcinoma; mouse model; skin cancer; ptc1; ultraviolet radiation; cancer; chemoprevention;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Aszterbaum, M San Francisco Gen Hosp, Room 269,Bldg 100,1001 Potrero Ave, San Francisco,CA 94110 USA San Francisco Gen Hosp Room 269,Bldg 100,1001 Potrero Ave San Francisco CA USA 94110
Citazione:
J.L. Hebert et al., "Chemoprevention of basal cell carcinomas in the ptc1(+/-) mouse - Green and black tea", SKIN PH APP, 14(6), 2001, pp. 358-362

Abstract

Skin cancers are a rising menace as their incidence increases, attributed in part to increasing ultraviolet radiation exposure. This increasing problem has stimulated efforts to devise useful preventive approaches. The uncertain efficacy of exhortations to avoid sun exposure and to use protective clothing and sunscreens to reduce damage when exposed argue for the development of an oral chemopreventive agent. Bickers and others have studied the effects and mechanisms of tea and of its putative active components on inhibition of skin cancer in experimental models. To continue this work, we havestudied the effects of oral green tea and black tea on a new model of ultraviolet-induced skin carcinogenesis - the development of basal cell carcinomas in ptc1(+/-) mice. To our surprise, we have found that tea preparationswhich others have used to prevent squamous cell carcinoma formation in mice fail to inhibit basal cell carcinogenesis in our model, suggesting that prevention of this cancer may require special, tumor-specific approaches. Copyright (C) 2001 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 09:23:04