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Titolo:
Beat-to-beat evaluation of cardiac function in low-dose endotoxemia using a conscious sheep model
Autore:
Abel, FL; Krosl, P; Redl, H;
Indirizzi:
Univ S Carolina, Dept Pharmacol & Physiol, Sch Med, Columbia, SC 29208 USAUniv S Carolina Columbia SC USA 29208 ol, Sch Med, Columbia, SC 29208 USA Ludwig Boltzmann Inst Expt & Clin Traumatol, Vienna, Austria Ludwig Boltzmann Inst Expt & Clin Traumatol Vienna Austria nna, Austria
Titolo Testata:
SHOCK
fascicolo: 5, volume: 16, anno: 2001,
pagine: 368 - 372
SICI:
1073-2322(200111)16:5<368:BEOCFI>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
NECROSIS-FACTOR-ALPHA; MYOCARDIAL-FUNCTION; LEFT-VENTRICLE; PRESSURE; END; CARDIOMYOCYTES; EXPRESSION; INDICATOR; SEPSIS; SLOPE;
Keywords:
sepsis; left ventricular function; endotoxin; ventricular compliance; P-max; end systolic elastance;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Abel, FL Univ S Carolina, Dept Pharmacol & Physiol, Sch Med, Columbia, SC 29208 USA Univ S Carolina Columbia SC USA 29208 ed, Columbia, SC 29208 USA
Citazione:
F.L. Abel et al., "Beat-to-beat evaluation of cardiac function in low-dose endotoxemia using a conscious sheep model", SHOCK, 16(5), 2001, pp. 368-372

Abstract

The effects of very low doses of endotoxin (20 ng/kg/h for 8 h) were evaluated in a conscious sheep model in which introducers for catheters for monitoring pressure and ventricular dimensions had been previously inserted so that the studies could be performed without anesthesia and without a previous thoracotomy. Analog data was obtained at hourly intervals for 10 h and again at 24 h and was used to construct a beat-to-beat analysis of left ventricular performance, Only minimal effects were observed on heart rate, end diastolic pressure, arterial pressure, cardiac output, or cardiac work, although there was a significant rise in pulmonary artery pressure at 1 h of infusion. Despite the absence of changes in heart rate, preload, or afterload, maximal dp/dt decreased significantly by 4 h and remained decreased for the 10-h observation period; it returned to normal at 24 h. End systolic elastance decreased at 6 h and P-max/EDV, a new indicator of performance, also decreased at 6 and 9 h. Thus, systolic performance decreased. Negative dp/dt did not change, but time for relaxation from 80% to 20% of peak ventricular pressure increased significantly at 5, 6, and 8 h. Plasma TNF-alpha was also measured and showed a significant rise at 2 h, but rapidly decreasedthereafter. These results indicate an early depression of myocardial contractility and distensibility at doses of endotoxin insufficient to produce measurable effects on arterial pressure or cardiac output.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/21 alle ore 03:24:19