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Titolo:
Studies on dopaminergic and GABAergic markers in striatum reveals a decrease in the dopamine transporter in schizophrenia
Autore:
Dean, B; Hussain, T;
Indirizzi:
Mental Hlth Res Inst, Div Mol Schizophrenia, Rebecca Cooper Res Labs, Parkville, Vic 3052, Australia Mental Hlth Res Inst Parkville Vic Australia 3052 le, Vic 3052, Australia Univ Melbourne, Dept Psychiat, Parkville, Vic 3052, Australia Univ Melbourne Parkville Vic Australia 3052 arkville, Vic 3052, Australia Monash Univ, Dept Med Psychol, Clayton, Vic 3006, Australia Monash Univ Clayton Vic Australia 3006 chol, Clayton, Vic 3006, Australia
Titolo Testata:
SCHIZOPHRENIA RESEARCH
fascicolo: 1-2, volume: 52, anno: 2001,
pagine: 107 - 114
SICI:
0920-9964(20011001)52:1-2<107:SODAGM>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; NITRIC-OXIDE SYNTHASE; UPTAKE SITES; HUMAN-BRAIN; AUTORADIOGRAPHIC DISTRIBUTION; PARKINSONS-DISEASE; POSTMORTEM BRAIN; D2 RECEPTORS; D1; BINDING;
Keywords:
dopamine receptors; dopamine transporter; GABA(A) receptor; nitric oxide synthase; schizophrenia; striatum;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Dean, B Mental Hlth Res Inst, Div Mol Schizophrenia, Rebecca Cooper Res Labs, Parkville, Vic 3052, Australia Mental Hlth Res Inst Parkville Vic Australia 3052 3052, Australia
Citazione:
B. Dean e T. Hussain, "Studies on dopaminergic and GABAergic markers in striatum reveals a decrease in the dopamine transporter in schizophrenia", SCHIZOPHR R, 52(1-2), 2001, pp. 107-114

Abstract

Changes in the interaction between dopaminergic and GABAergic systems in the striatum have been suggested to be important in the pathology of schizophrenia. If that hypothesis is correct, these changes could produce inter-related changes in the dopaminergic and GABAergic systems in the striatum from schizophrenic subjects. To test this proposition we measured important markers on dopaminergic and GABAergic neurons in striatum obtained post-mortem from schizophrenic and nonschizophrenic subjects. There was a significantdecrease in the density of the dopamine transporter (mean SEM: 230 +/- 31 vs. 334 +/- 22 fmol/mg ETE; P = 0.01), but not nitric oxide synthase, dopamine D-2-like, D-1-like, D-3 or GABA(A) receptors in subjects with schizophrenia. There were no inter-related changes in the dopaminergic or GABAergic markers. In the schizophrenic subjects, the density of dopamine D-1-like receptors decreased with age and was positively correlated with the density of dopamine D-2-like receptors. This study does not readily add weight to the hypothesis that changes in the interaction between dopamine and GABA in the striatum are important in the pathology of schizophrenia. However, our findings could indicate that changes in the dopamine transporter within the striatum, either because of decreased transporter numbers per se or as a result of innervating neuronal loss, may be involved in the pathology of the illness. (C) 2001 Elsevier Science B.V. All rights reserved.

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Documento generato il 02/04/20 alle ore 19:23:37