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Titolo:
A longitudinal study of hippocampal volume in first episode psychosis and chronic schizophrenia
Autore:
Wood, SJ; Velakoulis, D; Smith, DJ; Bond, D; Stuart, GW; McGorry, PD; Brewer, WJ; Bridle, N; Eritaia, J; Desmond, P; Singh, B; Copolov, D; Pantelis, C;
Indirizzi:
Univ Melbourne, Cognit Neuropsychiat Res & Acad Unit, Melbourne, Vic, Australia Univ Melbourne Melbourne Vic Australia d Unit, Melbourne, Vic, Australia Univ Melbourne, Dept Psychiat, Melbourne, Vic, Australia Univ Melbourne Melbourne Vic Australia ychiat, Melbourne, Vic, Australia Sunshine Hosp, Melbourne, Vic, Australia Sunshine Hosp Melbourne Vic Australia ne Hosp, Melbourne, Vic, Australia Mental Hlth Res Inst Victoria, Appl Schizophrenia Div, Melbourne, Vic, Australia Mental Hlth Res Inst Victoria Melbourne Vic Australia ne, Vic, Australia Royal Melbourne Hosp, Dept Radiol, Melbourne, Vic, Australia Royal Melbourne Hosp Melbourne Vic Australia , Melbourne, Vic, Australia EPPIC, Melbourne, Vic, Australia EPPIC Melbourne Vic AustraliaEPPIC, Melbourne, Vic, Australia
Titolo Testata:
SCHIZOPHRENIA RESEARCH
fascicolo: 1-2, volume: 52, anno: 2001,
pagine: 37 - 46
SICI:
0920-9964(20011001)52:1-2<37:ALSOHV>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHILDHOOD-ONSET SCHIZOPHRENIA; SUPERIOR TEMPORAL GYRUS; BRAIN STRUCTURAL-CHANGE; MAGNETIC-RESONANCE; FOLLOW-UP; HIGH-RISK; LOBE STRUCTURES; GRAY-MATTER; REDUCTION; ADOLESCENCE;
Keywords:
schizophrenia; hippocampus; neurodegeneration; NEU; volumetry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Wood, SJ Mental Hlth Res Inst, Locked Bag 11, Parkville, Vic 3052, Australia Mental Hlth Res Inst Locked Bag 11 Parkville Vic Australia 3052 a
Citazione:
S.J. Wood et al., "A longitudinal study of hippocampal volume in first episode psychosis and chronic schizophrenia", SCHIZOPHR R, 52(1-2), 2001, pp. 37-46

Abstract

Brain abnormalities have been identified in patients with schizophrenia, but what is unclear is whether these changes are progressive over the courseof the disorder. In this longitudinal study, hippocampal and temporal lobevolumes were measured at two time points in 30 patients with first episodepsychosis (mean follow-up interval = 1.9 years, range 0.54-4.18 years) and12 with chronic schizophrenia (mean follow-up interval = 2.3 years, range 1.03-4.12 years) and compared to 26 comparison subjects (mean follow-up interval 2.2 years, range 0.86-4.18 years). Hippocampal, temporal lobe, whole-brain and intracranial volumes (ICV) were estimated from high-resolution magnetic resonance images. Only whole-brain volume showed significant loss over the follow-up interval in both patient groups. The rate of this volume loss was not different in the first episode group compared to the chronic group. There were no changes in either hippocampal or temporal lobe volumes. The negative findings for the hippocampus and temporal lobes may mean that the abnormalities in these regions are stable features of schizophrenia. Alternatively, the period before the onset of frank psychotic symptoms may bethe point of greatest risk for progressive change. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 01:29:27