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Titolo:
Duration of untreated psychosis as a predictor of outcome in first-episodeschizophrenia: a retrospective study
Autore:
Altamura, AC; Bassetti, R; Sassella, F; Salvadori, D; Mundo, E;
Indirizzi:
Univ Milan, Luigi Sacco Hosp, Inst Biomed Sci, Dept Psychiat, I-20157 Milan, Italy Univ Milan Milan Italy I-20157 Sci, Dept Psychiat, I-20157 Milan, Italy
Titolo Testata:
SCHIZOPHRENIA RESEARCH
fascicolo: 1-2, volume: 52, anno: 2001,
pagine: 29 - 36
SICI:
0920-9964(20011001)52:1-2<29:DOUPAA>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
QUALITY-OF-LIFE; EARLY INTERVENTION; TREATMENT RESPONSE; FOLLOW-UP; 1ST-EPISODE SCHIZOPHRENIA; NEGATIVE SYMPTOMS; RELAPSE; ONSET; TERM; NEUROLEPTICS;
Keywords:
schizophrenia; first episode; clinical predictors; duration of untreated psychosis; outcome;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
59
Recensione:
Indirizzi per estratti:
Indirizzo: Altamura, AC Univ Milan, Luigi Sacco Hosp, Inst Biomed Sci, Dept Psychiat,VIA GB Grassi 74, I-20157 Milan, Italy Univ Milan VIA GB Grassi 74 Milan Italy I-20157 Milan, Italy
Citazione:
A.C. Altamura et al., "Duration of untreated psychosis as a predictor of outcome in first-episodeschizophrenia: a retrospective study", SCHIZOPHR R, 52(1-2), 2001, pp. 29-36

Abstract

The aim of this study was to investigate possible clinical predictors of the outcome of first-episode schizophrenia. The clinical charts of the firstepisode of psychosis and the follow-up period over at least 4 years for 67DSM-IH-R schizophrenic patients were reviewed. According to the number of psychotic relapses observed during the follow-up period, patients were sub-divided into two groups: mono- and multi-episode patients. The main demographic and clinical variables recorded at the first episode were compared between the two groups. A logistic regression analysis was performed to test amodel for the possible predictors of the two different patterns of outcome. Multi-episode patients had an earlier onset of the illness and a longer "duration of untreated psychosis" (DUP), defined as the interval between the onset of the first psychotic symptoms and the first antipsychotic treatment. The Brief Psychiatric Rating Scale (BPRS) total scores were lower and the"avolition/apathy" scores of the scale for the assessment of negative symptoms (SANS) were higher in multi-episode patients. The logistic regression analysis results confirmed the DUP and the pre-treatment BPRS scores to be significant predictors of the outcome. These findings confirm that the timing in recognizing and treating the early symptoms of schizophrenia, even when subtle, is a core issue for the clinical management of the disorder. (C)2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 16:02:58