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Titolo:
Coagulation system activity before coronary artery bypass surgery for unstable angina
Autore:
Bjessmo, S; Ivert, T; Egberg, N;
Indirizzi:
Karolinska Hosp, Thorac Surg Clin, Dept Thorac Surg, SE-17176 Stockholm, Sweden Karolinska Hosp Stockholm Sweden SE-17176 rg, SE-17176 Stockholm, Sweden Karolinska Hosp, Dept Clin Chem & Blood Coagulat, SE-17176 Stockholm, Sweden Karolinska Hosp Stockholm Sweden SE-17176 at, SE-17176 Stockholm, Sweden
Titolo Testata:
SCANDINAVIAN CARDIOVASCULAR JOURNAL
fascicolo: 4, volume: 35, anno: 2001,
pagine: 280 - 284
SICI:
1401-7431(200109)35:4<280:CSABCA>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLASMINOGEN-ACTIVATOR INHIBITOR; MYOCARDIAL-INFARCTION; ANTITHROMBIN-III; COMPLEX; PLASMA; DEGRADATION; PREDICTORS; PECTORIS; DISEASE; EVENTS;
Keywords:
coronary artery bypass surgery; unstable angina; coagulation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Bjessmo, S Karolinska Hosp, Thorac Surg Clin, Dept Thorac Surg, SE-17176 Stockholm, Sweden Karolinska Hosp Stockholm Sweden SE-17176 6 Stockholm, Sweden
Citazione:
S. Bjessmo et al., "Coagulation system activity before coronary artery bypass surgery for unstable angina", SC CARDIOVA, 35(4), 2001, pp. 280-284

Abstract

Objective - To measure coagulation activity immediately prior to coronary artery bypass surgery. Previous reports have shown that a hypercoagulable state and reduced fibrinolytic activity increase the risk of postoperative graft failure. Design - Fifty patients with unstable angina and ongoing low-molecular-weight heparin antithrombotic treatment for a median of 4 days and 25 stable patients undergoing elective surgery were included. Results - Antithrombin levels were significantly lower whereas fibrinogen and plasminogen activator inhibitor-1 levels were higher in the unstable patients than in the stable patients. Median preoperative levels of thrombin-antithrombin complex (TAT), prothrombin fragment(1+2) (F1+2), fibrin D-dimers and beta-thromboglobulin did not differ significantly in unstable and stable patients. There were si-ns of activated coagulation with elevated levels of TAT and F1+2 before the operation in half of the unstable patients, who had had chest pain at rest within 48 h preceding the operation and also in one-third of patients undergoing elective surgery. Conclusion - A hypercoagulable state may be present in unstable as well asin stable angina pectoris patients accepted for coronary artery bypass surgery.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 09:44:41