Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Better preserved pulmonary endothelium-dependent vasodilation with off-pump coronary surgery
Autore:
Angdin, M; Settergren, G; Vaage, J;
Indirizzi:
Karolinska Hosp, Dept Cardiothorac Anesthesia & Intens Care, Div Thorac Surg, SE-17176 Stockholm, Sweden Karolinska Hosp Stockholm Sweden SE-17176 rg, SE-17176 Stockholm, Sweden Karolinska Inst, Div Cardiothorac Anaesthet & Intens Care, Dept Surg Sci, S-10521 Stockholm, Sweden Karolinska Inst Stockholm Sweden S-10521 Sci, S-10521 Stockholm, Sweden
Titolo Testata:
SCANDINAVIAN CARDIOVASCULAR JOURNAL
fascicolo: 4, volume: 35, anno: 2001,
pagine: 264 - 269
SICI:
1401-7431(200109)35:4<264:BPPEVW>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARDIOPULMONARY BYPASS; NITRIC-OXIDE; COMPLEMENT ACTIVATION; TISSUE-INJURY; ARTERY; ACETYLCHOLINE; REPERFUSION; ISCHEMIA; DYSFUNCTION; REACTIVITY;
Keywords:
acetylcholine; cardiopulmonary bypass; coronary artery bypass grafting; endothelial function; off-pump surgery; pulmonary vascular resistance;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Angdin, M Karolinska Hosp, Dept Cardiothorac Anesthesia & Intens Care, DivThorac Surg, SE-17176 Stockholm, Sweden Karolinska Hosp Stockholm SwedenSE-17176 76 Stockholm, Sweden
Citazione:
M. Angdin et al., "Better preserved pulmonary endothelium-dependent vasodilation with off-pump coronary surgery", SC CARDIOVA, 35(4), 2001, pp. 264-269

Abstract

Objective - To investigate if endothelium-dependent vasodilation in the pulmonary circulation was better maintained after off-pump coronary artery bypass grafting, (CABG). An impaired pulmonary vascular response to acetylcholine has been observed after cardiopulmonary bypass (CPB) in children, adults and experimentally. Design - Fourteen patients operated off-pump were compared with 21 patients undergoing conventional CABG with CPB. The indexed pulmonary vascular resistance was measured before and durino, an infusion of acetylcholine, aiming at a concentration of 10(-6) Mol/l in the pulmonary artery. Twelve patients operated on-pump received saline instead of acetylcholine. Results - Before surgery pulmonary vascular resistance decreased during infusion of acetylcholine by 28% and 25% in the off-pump and on-pump groups. After surgery the decrease was 16% and 6%, respectively (p = 0.028 and p < 0.001, compared to preoperative response). The response did not differ between the two groups before, but did so after surgery (p = 0.01). Saline had no effect. Conclusion - The better maintained endothelium-dependent vasodilation in the off-pump group indicated less endothelial dysfunction.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 00:35:53