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Titolo:
Tc-99M-Sestamibi SPECT is a useful technique for viability detection - Results of a comparison with NH3/FDG PET
Autore:
Kaltoft, A; Bottcher, M; Sand, NPR; Flo, C; Nielsen, TT; Rehling, M;
Indirizzi:
Aarhus Univ Hosp, Skejby Sygehus, Dept Nucl Med, DK-8200 Aarhus N, DenmarkAarhus Univ Hosp Aarhus Denmark N pt Nucl Med, DK-8200 Aarhus N, Denmark Aarhus Univ Hosp, Skejby Sygehus, Dept Cardiol, DK-8200 Aarhus, Denmark Aarhus Univ Hosp Aarhus Denmark DK-8200 Cardiol, DK-8200 Aarhus, Denmark
Titolo Testata:
SCANDINAVIAN CARDIOVASCULAR JOURNAL
fascicolo: 4, volume: 35, anno: 2001,
pagine: 245 - 251
SICI:
1401-7431(200109)35:4<245:TSIAUT>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY-ARTERY DISEASE; LEFT-VENTRICULAR DYSFUNCTION; POSITRON-EMISSION-TOMOGRAPHY; MYOCARDIAL VIABILITY; TC-99M SESTAMIBI; METHOXYISOBUTYL ISONITRILE; HIBERNATING MYOCARDIUM; COMPUTED-TOMOGRAPHY; TECHNETIUM-99M-SESTAMIBI; TL-201;
Keywords:
viability; ischemic cardiomyopathy; 99(m)Tc-Sestamibi-SPECT; NH3/FDG PET;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Kaltoft, A Aarhus Univ Hosp, Skejby Sygehus, Dept Nucl Med, DK-8200 AarhusN, Denmark Aarhus Univ Hosp Aarhus Denmark N , DK-8200 Aarhus N, Denmark
Citazione:
A. Kaltoft et al., "Tc-99M-Sestamibi SPECT is a useful technique for viability detection - Results of a comparison with NH3/FDG PET", SC CARDIOVA, 35(4), 2001, pp. 245-251

Abstract

Objective - Assessment of myocardial viability by Tc-99m-Sestamibi Single Photon Emission Computerized Tomography (SPECT) has been suggested as a more readily available and cheaper alternative to Positron Emission Tomography(PET) with N-13-ammonia (NH3) and F-18-fluoro-deoxy-glucose (FDG). We hypothesized that a semiquantitative evaluation by SPECT could delineate myocardial viability with an acceptable concordance to PET. Design - Fifty patients (age 57 +/- 7 years; ejection fraction 28 +/- 8%),with ischemic cardiomyopathy, underwent SPECT and PET imaging in random order. Viability by SPECT was defined as a defect size < 50% of the segment area, or a defect representing greater than or equal to 50% of the segment but with a mean activity 50% of peak activity. PET viability was defined as a perfusion score >2 and FDG score <2 (five-point scale, 0 = normal, 4 = absent activity). Results - By segmental comparison to PET, SPECT yielded a sensitivity and specificity of 87% and 82% for detection of viable myocardium. The positiveand negative predictive values were 96% and 58%. respectively. Conclusion - In patients with severe ischemic cardiomyopathy Tc-99m-Sestamibi SPECT can delineate viable myocardium with an acceptable segmental concordance to NH3/FDG PET.

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Documento generato il 20/06/19 alle ore 17:03:02