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Titolo:
Epidemiological consequences of introducing new biochemical markers for detection of acute myocardial infarction
Autore:
Graven, T; Kruger, O; Bronstad, G;
Indirizzi:
Innherred Sykehus, Dept Internal Med, NO-7600 Levanger, Norway Innherred Sykehus Levanger Norway NO-7600 Med, NO-7600 Levanger, Norway Norwegian Univ Sci & Technol, Dept Community Med & Gen Practice, N-7034 Trondheim, Norway Norwegian Univ Sci & Technol Trondheim Norway N-7034 4 Trondheim, Norway Innherred Sykehus, Cent Lab, NO-7600 Levanger, Norway Innherred Sykehus Levanger Norway NO-7600 Lab, NO-7600 Levanger, Norway
Titolo Testata:
SCANDINAVIAN CARDIOVASCULAR JOURNAL
fascicolo: 4, volume: 35, anno: 2001,
pagine: 233 - 237
SICI:
1401-7431(200109)35:4<233:ECOINB>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARDIAC TROPONIN-I; CORONARY HEART-DISEASE; PROGNOSTIC VALUE; CK-MB; UNSTABLE ANGINA; TRENDS; SPECIFICITY; MORTALITY; INJURY; MASS;
Keywords:
acute myocardial infarction; biochemical markers; epidemiology;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Graven, T Innherred Sykehus, Dept Internal Med, NO-7600 Levanger, Norway Innherred Sykehus Levanger Norway NO-7600 600 Levanger, Norway
Citazione:
T. Graven et al., "Epidemiological consequences of introducing new biochemical markers for detection of acute myocardial infarction", SC CARDIOVA, 35(4), 2001, pp. 233-237

Abstract

Objective - To evaluate how the use of different biochemical markers of myocardial injury affects the recorded numbers of cases of diagnosed acute myocardial infarction (AMI) and unstable angina pectoris (UAP) and also the observed in-hospital mortality of AMI. Design - 442 patients admitted with suspected acute coronary syndrome (ACS) were studied. Based on the World Health Organization (WHO) criteria, the patients were classified into five categories: acute Q-wave myocardial infarction (QMI); acute non-Q-wave myocardial infarction (NQMI); UAP; stable angina pectoris; and chest pain of non-cardiac origin. Results - Using total creatine kinase (tCK) as the "gold standard" for diagnosis, we found 172 AMI, 100 UAP and 170 with other diagnoses. If we used CK-MB (>6 mug/L) or cTnI (>1 mug/L) for diagnosing AMI, the numbers of AMI increased significantly by 50 (29%) and 64 (37%), respectively. Using tCk. CK-MB or cTnI for diagnosing AMI, the observed in-hospital mortality was 14%, 11% and 10%, respectively. The group of patients with elevated cTnI but negative tCK had similar long-term survival as the group of patients with cTn1 > 30 mug/L, comprising 95% of the patients with the diagnosis AMI basedon tCK. Conclusion - The introduction of new biochemical markers for detection of AMI may lead to significant changes in the recorded incidence and in-hospital mortality of AMI. New biochemical markers of myocardial injury must be validated against the traditional markers as they are introduced into clinical practice by the new diagnostic criteria.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 14:32:04