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Titolo:
PHARMACOKINETICS OF AMPICILLIN AND SULFADIMIDINE IN PIGS INFECTED EXPERIMENTALLY WITH STREPTOCOCCUS-SUUM
Autore:
YUAN ZH; MIAO XQ; YIN YH;
Indirizzi:
CENT CHINA AGR UNIV,COLL ANIM SCI & VET MED,DEPT VET BASIC SCI WUHAN 430070 HUBEI PEOPLES R CHINA
Titolo Testata:
Journal of veterinary pharmacology and therapeutics
fascicolo: 4, volume: 20, anno: 1997,
pagine: 318 - 322
SICI:
0140-7783(1997)20:4<318:POAASI>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
TICK-BORNE FEVER; RENAL CLEARANCE; CALVES; FASCIOLIASIS; ANTIPYRINE; METABOLITE; ENDOTOXIN; FAILURE; SHEEP; GOATS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
Z.H. Yuan et al., "PHARMACOKINETICS OF AMPICILLIN AND SULFADIMIDINE IN PIGS INFECTED EXPERIMENTALLY WITH STREPTOCOCCUS-SUUM", Journal of veterinary pharmacology and therapeutics, 20(4), 1997, pp. 318-322

Abstract

Twenty-three hybrid pigs (23 +/- 3 kg body wt) were assigned to threegroups to investigate the pharmacokinetics of ampicillin (APC, 10 mg/kg) administered intravenously (i.v.) and intramuscularly (i.m.), and sulfadimidine (SDM, 50 mg/kg) administered intravenously as a bolus injection, In the first series of experiments the animals remained healthy. Subsequently, the pigs were infected with Streptococcus suum by subcutaneous (s.c.) inoculation and the experiments were repeated. The total apparent distribution volume of APC given intravenously was increased from 0.512 +/- 0.026 L/kg in uninfected pigs to 0.68 +/- 0.06 L/kg (P < 0.01) in infected pigs, whereas there were no significant changes in the same parameter for SDM (P > 0.05). The clearance of APC was increased markedly from 0.52 +/- 0.07 L/kg/h in uninfected pigs to 0.62 +/- 0.10 L/kg/h in infected pigs. In contrast, SDM clearance was decreased markedly from 0.023 +/- 0.003 L/kg/h to 0.017 +/- 0.003 L/kg/h (P < 0.05). As a result, the biological half-lives of the drugs were altered to varying degrees in infected pigs, The half-life of SDM was increased from 15.0 +/- 3.0 h in uninfected pigs to 30 +/- 7h in infected pigs (P < 0.05), but differences in APC half-lives between uninfected and infected animals were not observed (P > 0.05), There were no statistically significant differences in pharmacokinetic parameters of APC administered by intramuscular injection between the healthy and thediseased status, although its half-lift was shortened from 0.76 +/- 0.22 h in the healthy to 0.57 +/- 0.23 h in the diseased. The results suggest that blood concentrations of APC and SDM are affected differently by the same disease due to its specific effects on their distribution and elimination.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 22:50:56