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Titolo:
Effect of gabapentin-like compounds on development and maintenance of morphine-induced conditioned place preference
Autore:
Andrews, N; Loomis, S; Blake, R; Farrigan, L; Singh, L; McKnight, AT;
Indirizzi:
Organon Labs Ltd, Newhouse ML1 5SH, Lancs, England Organon Labs Ltd Newhouse Lancs England ML1 5SH e ML1 5SH, Lancs, England Univ Cambridge, Cambridge Labs, Pfizer Global R&D, Cambridge CB2 2QB, England Univ Cambridge Cambridge England CB2 2QB R&D, Cambridge CB2 2QB, England
Titolo Testata:
PSYCHOPHARMACOLOGY
fascicolo: 4, volume: 157, anno: 2001,
pagine: 381 - 387
Fonte:
ISI
Lingua:
ENG
Soggetto:
RANDOMIZED CONTROLLED TRIAL; VENTRAL TEGMENTAL AREA; NUCLEUS-ACCUMBENS; H-3 GABAPENTIN; OPIATE REWARD; RATS; DOPAMINE; AMPHETAMINE; MECHANISMS; COCAINE;
Keywords:
gabapentin-like compounds; morphine; conditioned place preference;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Andrews, N Organon Labs Ltd, Newhouse ML1 5SH, Lancs, England Organon LabsLtd Newhouse Lancs England ML1 5SH Lancs, England
Citazione:
N. Andrews et al., "Effect of gabapentin-like compounds on development and maintenance of morphine-induced conditioned place preference", PSYCHOPHAR, 157(4), 2001, pp. 381-387

Abstract

Rationale: Psychological dependence to the opioid analgesic morphine is attributable to the rewarding properties of the drug, and its evolution can be divided into two distinct phases: development and maintenance. Both phases can be studied using conditioned place preference (CPP). Objectives: To determine whether the two phases can be influenced by pre-treatment with gabapentin-like compounds. Methods: CPP to morphine was used to demonstrate the rewarding properties of morphine in the presence or absence of gabapentin-like compounds. In-vivo microdialysis in the nucleus accumbens was used todetermine the effects of gabapentin or pregabalin on morphine-induced dopamine release. Results: Pretreatment with either gabapentin (10-100 mg/kg p.o.) or pregabalin (3-30 mg/kg p.o.) attenuated CPP induced by a submaximal dose of morphine (0.75 mg/kg). Neither gabapentin nor pregabalin had any effect alone in the CPP test. Both gabapentin-like compounds blocked the effect of morphine (0.75 mg/kg s.c.) to increase the release of dopamine in thenucleus accumbens. Studies of the maintenance of CPP to morphine showed CPP was maintained for at least 4 days after the initial test. In a second experiment, it was found that pregabalin (injected once, 24 h after CPP had been demonstrated) was able to reverse morphine-induced CPP. Conclusions: Neither gabapentin nor pregabalin induced CPP, but both compounds blocked thedevelopment of CPP to morphine and also blocked morphine's effects on dopamine release. Furthermore, pregabalin blocked the maintenance of morphine-induced CPP. It is concluded that gabapentin-like compounds, which have no intrinsic rewarding properties, may have some therapeutic use in the treatment of opioid dependence.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 07:11:46