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Titolo:
Significance of platelet aggregability immediately after blood sampling and effect of cigarette smoking
Autore:
Inoue, T; Hayashi, M; Uchida, T; Takayanagi, K; Hayashi, T; Morooka, S;
Indirizzi:
Dokkyo Univ, Sch Med, Koshigaya Hosp, Dept Cardiol, Koshigaya, Saitama 3438555, Japan Dokkyo Univ Koshigaya Saitama Japan 3438555 igaya, Saitama 3438555, Japan Dokkyo Univ, Sch Med, Koshigaya Hosp, Dept Obstet & Gynecol, Koshigaya, Saitama, Japan Dokkyo Univ Koshigaya Saitama Japan & Gynecol, Koshigaya, Saitama, Japan
Titolo Testata:
PLATELETS
fascicolo: 7, volume: 12, anno: 2001,
pagine: 415 - 418
SICI:
0953-7104(200111)12:7<415:SOPAIA>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACTIVATION; MEMBRANE; GLYCOPROTEIN; AGGREGATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
11
Recensione:
Indirizzi per estratti:
Indirizzo: Inoue, T Dokkyo Univ, Sch Med, Koshigaya Hosp, Dept Cardiol, 2-1-50 Minamikoshigaya, Koshigaya, Saitama 3438555, Japan Dokkyo Univ 2-1-50 Minamikoshigaya Koshigaya Saitama Japan 3438555
Citazione:
T. Inoue et al., "Significance of platelet aggregability immediately after blood sampling and effect of cigarette smoking", PLATELETS, 12(7), 2001, pp. 415-418

Abstract

A novel type platelet aggregometer, a WBA Analyzer, has enabled us to obtain the platelet aggregability data immediately after blood sampling, which is considered to closely reflect in vivo platelet function. Using this analyzer, we measured the platelet aggregatory threshold index (PATI) 5 min after blood sampling and compared it with that 60 min after blood sampling in 20 healthy male volunteers (10 smokers and 10 nonsmokers). In the non-smokers, PATI was 10.3 +/-2.3 muM 5 min after blood sampling, and it decreased to 4.7 +/-1.5 (P<0.001) 60 min after blood sampling. In the smokers, the PATI was 7.7<plus/minus>2.9 muM 5 min after blood sampling, and it decreased to 3.8 +/-1.5 (P<0.001) at 60 min after blood sampling. In the smokers, the PATI 5 min after blood sampling increased after a 4-week cessation of smoking (10.4<plus/minus>2.9, P<0.01), although the PATI 60 min after blood sampling did not change (4.2<plus/minus>1.6 muM). The measurement of platelet aggregability immediately after blood sampling using a WBA Analyser may be useful to evaluate not only platelet function in various thrombotic disorders, but also the effects of various anti-platelet drugs. Cessation of smoking should also be encouraged in the light of the adverse effects on plateletfunction.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/05/20 alle ore 14:50:22