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Titolo:
Effect of ginseng saponins on beta-amyloid-suppressed acetylcholine release from rat hippocampal slices
Autore:
Lee, TF; Shiao, YJ; Chen, CF; Wang, LCH;
Indirizzi:
Univ Alberta, Dept Sci Biol, Edmonton, AB T6G 2E9, Canada Univ Alberta Edmonton AB Canada T6G 2E9 iol, Edmonton, AB T6G 2E9, Canada Natl Yang Ming Med Coll, Inst Pharmacol, Taipei 11221, Taiwan Natl Yang Ming Med Coll Taipei Taiwan 11221 rmacol, Taipei 11221, Taiwan
Titolo Testata:
PLANTA MEDICA
fascicolo: 7, volume: 67, anno: 2001,
pagine: 634 - 637
SICI:
0032-0943(200110)67:7<634:EOGSOB>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
SENESCENCE-ACCELERATED MOUSE; LEARNING-PERFORMANCE; PRECURSOR PROTEIN; GINSENOSIDES; PRESCRIPTION; METABOLISM; IMPROVES; PEPTIDE; MEMORY;
Keywords:
Panax quinquefolius L.; Araliaceae; ginsenosides; beta-amyloid; acetylcholine release; hippocampus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Wang, LCH Univ Alberta, Dept Sci Biol, Biol Sci Bldg, Edmonton, AB T6G 2E9, Canada Univ Alberta Biol Sci Bldg Edmonton AB Canada T6G 2E9 E9, Canada
Citazione:
T.F. Lee et al., "Effect of ginseng saponins on beta-amyloid-suppressed acetylcholine release from rat hippocampal slices", PLANTA MED, 67(7), 2001, pp. 634-637

Abstract

In view of the facts that ginseng has been shown to improve age-related memory deficits and beta -amyloid-related peptides have been suggested to play a significant role in memory degeneration in the elderly, the present study was carried out to examine the effect of various ginsenosides on beta -amyloid peptides-modulated acetylcholine (ACh) release, a key neurotransmitter in memory processing, from the hippocampal slices. Addition of beta -amyloid fragment(25-35) (0.01-1 muM) in the superfusion medium suppressed the K+-evoked [H-3]-ACh release from the rat hippocampal slices in a concentration-related manner and about 40% reduction in ACh outflow was observed whenincubating with the highest concentration of an amyloid fragment (1 muM). Inclusion of the ginsenoside components Rb-1 (0.1 muM), but not Rg(1), caused a rightward shift of the concentration-response curve of beta -amyloid. The reversal of the beta -amyloid-inhibited ACh release by Rb-1 was not blocked by tetrodotoxin (1 muM) indicating that an interaction occurs at the cholinergic synapse. These results suggest that Rb-1 may elicit its anti-amnesic effect by minimizing the inhibitory effect of beta -amyloid peptides.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 10:01:03