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Titolo:
Capsaicin-like anti-obese activities of evodiamine from fruits of Evodia rutaecarpa, a vanilloid receptor agonist
Autore:
Kobayashi, Y; Nakano, Y; Kizaki, M; Hoshikuma, K; Yokoo, Y; Kamiya, T;
Indirizzi:
Kyowa Hakko Kogyo Co Ltd, Tsukuba Res Labs, Tsukuba, Ibaraki 3050841, Japan Kyowa Hakko Kogyo Co Ltd Tsukuba Ibaraki Japan 3050841 aki 3050841, Japan
Titolo Testata:
PLANTA MEDICA
fascicolo: 7, volume: 67, anno: 2001,
pagine: 628 - 633
SICI:
0032-0943(200110)67:7<628:CAAOEF>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
BROWN-ADIPOSE-TISSUE; BODY-TEMPERATURE; RATS; THERMOGENESIS; HYPOTHERMIA; ANALOGS;
Keywords:
evodiamine; capsaicin; vanilloid receptor; Evodia rutaecarpa; Rutaceae; obesity treatment;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Kobayashi, Y Kyowa Hakko Kogyo Co Ltd, Tsukuba Res Labs, 2 Miyukigaoka, Tsukuba, Ibaraki 3050841, Japan Kyowa Hakko Kogyo Co Ltd 2 Miyukigaoka Tsukuba Ibaraki Japan 3050841
Citazione:
Y. Kobayashi et al., "Capsaicin-like anti-obese activities of evodiamine from fruits of Evodia rutaecarpa, a vanilloid receptor agonist", PLANTA MED, 67(7), 2001, pp. 628-633

Abstract

Evodiamine, a major alkaloidal principle of Evodia fruits (Evodia rutaecarpa, Rutaceae), showed vanilloid receptor agonistic activities comparable tocapsaicin. The Chinese literature refers to Evodia fruits as a "hot nature" herb. In spite of the similarities in the actions of evodiamine and capsaicin in vitro, evodiamine has no perceptible taste, including a peppery hottaste. Therefore, the effectiveness of evodiamine and the extract of Evodia fruits in preventing obesity on male C3H mice, or male SD rats were examined. When evodiamine was supplemented at 0.03% of the diet and fed to mice for 12 days, the perirenal fat weight became significantly lower than in the control group. The epididymal fat mass was also decreased in the evodiamine diet group. When evodiamine was supplemented at 0.02% in the form of ethanol extract of Evodia fruits to the high-fat diet and fed to rats for 21 days, the body weight, the perirenal fat weight, epididymal fat weight, the levels of serum free fatty acid, total lipids in the liver, triglyceride inthe liver, and cholesterol level in the liver were significantly reduced as compared with the control diet group. Furthermore, both lipolytic activity in the perirenal fat tissue and specific GDP binding in brown adipose tissue mitochondria, as the biological index of enhanced heat production, weresignificantly increased in the evodiamine fed rats. Fasting mice subcutaneously administered 1-3 mg/kg evodiamine showed decreased core body temperature by 1-2 degreesC. This hypothermic effect was prevented by the pretreatment of intraperitoneally administered 10 mg/kg capsazepine, a vanilloid receptor antagonist. on the other hand, food-sated mice subcutaneously administered 1-3 mg/kg evodiamine showed unchanged core body temperature and increased tail skin temperature by more than 5 degreesC, suggesting the increased energy expenditure by enhanced heat dissipation. In conclusion, we have demonstrated that a novel non-pungent vanilloid receptor agonist, evodiamine, mimics the characteristic anti-obese effects induced by capsaicin. Evodiamine would induce heat loss and heat production at the same time and dissipate food energy, preventing the accumulation of perivisceral fat and the body weight increase.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 00:36:31