Catalogo Articoli (Spogli Riviste)

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Titolo:
Availability of learned helplessness test as a model of depression compared to a forced swimming test in rats
Autore:
Takamori, K; Yoshida, S; Okuyama, S;
Indirizzi:
Taisho Pharmaceut Co Ltd, Med Res Labs, Lab 1, Omiya, Saitama 3308530, Japan Taisho Pharmaceut Co Ltd Omiya Saitama Japan 3308530 itama 3308530, Japan
Titolo Testata:
PHARMACOLOGY
fascicolo: 3, volume: 63, anno: 2001,
pagine: 147 - 153
SICI:
0031-7012(2001)63:3<147:AOLHTA>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
GABA(B) RECEPTOR SYSTEMS; ANIMAL-MODEL; ANTIDEPRESSANTS; SEROTONIN; INVOLVEMENT; BACLOFEN;
Keywords:
amitriptyline; amoxapine; clomipramine; fluvoxamine; forced swimming test; imipramine; learned helplessness test; mianserin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Takamori, K Taisho Pharmaceut Co Ltd, Med Res Labs, Lab 1, 1-403 Yoshino Cho, Omiya, Saitama 3308530, Japan Taisho Pharmaceut Co Ltd 1-403 Yoshino Cho Omiya Saitama Japan 3308530
Citazione:
K. Takamori et al., "Availability of learned helplessness test as a model of depression compared to a forced swimming test in rats", PHARMACOL, 63(3), 2001, pp. 147-153

Abstract

This study was designed to evaluate the antidepressant activity of variousantidepressants using the learned helplessness test (LH) or the forced swimming test (FS) in rats. Repeated treatment of the tricyclic antidepressants imipramine (10 mg/kg, p.o.), clomipramine (0.625 mg/kg, p.o.), amitriptyline (10 mg/kg, p.o.) and amoxapine (20 mg/kg, p.o.) reduced the number of escape failures in the LH group, respectively. Repeated treatment of an atypical antidepressant, mianserin (2.5 and 5 mg/kg, p.o.), and one of the selective serotonin reuptake inhibitors (SSRI), fluvoxamine (1.25 mg/kg, p.o.),also reduced the number of escape failures in the LH group. In the FS, repeated treatment of imipramine (5, 10 mg/kg, p.o.), amitriptyline (5, 10 mg/kg, p.o.) and mianserin (10 mg/kg) significantly decreased the duration of immobility time. On the other hand, repeated treatment of amoxapine (5-20 mg/kg), clomipramine (0.1325-1.25 mg/kg, p.o.) and fluvoxamine (0.3125-1.25 mg/kg, p.o.) failed to decrease the duration of immobility time in the FS group. In conclusion, these results suggest that the LH group is sensitive to agents with a variety of antidepressant properties compared to the FS group in rats. Copyright 2001 (C) S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 04:25:35