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Titolo:
Neuromuscular blocking effects of the aminoglycoside antibiotics arbekacin, astromicin, isepamicin and netilmicin on the diaphragm and limb muscles in the rabbit
Autore:
Liu, MJ; Kato, M; Hashimoto, Y;
Indirizzi:
Tohoku Univ, Sch Med, Dept Anesthesiol, Aoba Ku, Sendai, Miyagi 9808574, Japan Tohoku Univ Sendai Miyagi Japan 9808574 Ku, Sendai, Miyagi 9808574, Japan
Titolo Testata:
PHARMACOLOGY
fascicolo: 3, volume: 63, anno: 2001,
pagine: 142 - 146
SICI:
0031-7012(2001)63:3<142:NBEOTA>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADDUCTOR POLLICIS MUSCLE; RESPIRATORY MUSCLES; BLOOD-FLOW; VECURONIUM; POTENCY; DIACYLGLYCEROL; ATRACURIUM; POLYMYXIN; BLOCKADE; BINDING;
Keywords:
aminoglycoside antibiotics; arbekacin; astromicin; isepamicin; netilmicin; neuromuscular blockade;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Hashimoto, Y Tohoku Univ, Sch Med, Dept Anesthesiol, Aoba Ku, 1-1 Seiryo Machi, Sendai,Miyagi 9808574, Japan Tohoku Univ 1-1 Seiryo Machi Sendai Miyagi Japan 9808574 apan
Citazione:
M.J. Liu et al., "Neuromuscular blocking effects of the aminoglycoside antibiotics arbekacin, astromicin, isepamicin and netilmicin on the diaphragm and limb muscles in the rabbit", PHARMACOL, 63(3), 2001, pp. 142-146

Abstract

Aminoglycoside antibiotics are known to produce a depression of neuromuscular function which may cause prolonged paralysis of respiratory muscles. However, differences in the effects of aminoglycoside antibiotics on diaphragm and limb muscles have not been investigated. We determined the neuromuscular blocking effects of the aminoglycoside antibiotics arbekacin sulfate, astromicin sulfate, isepamicin sulfate and netilmicin sulfate on the diaphragm, tibialis anterior and soleus muscles in anesthetized rabbit nerve-muscle preparations. Neuromuscular block was assessed by mechanical response with single twitch stimulation. Cumulative drug dose-response curves were obtained for three different muscles in 24 rabbits. The mean ED50 and ED95 of the antibiotics in diaphragm, tibialis anterior and soleus muscles were calculated. The neuromuscular blocking effects of all the aminoglycosides on ED50 and ED95 values were in the order of soleus > tibialis anterior > diaphragm, and soleus > diaphragm > tibialis anterior, respectively. The ED50 ratios for the tibialis anterior and soleus muscles were approximately 1.5 and2.7 times greater than that for the diaphragm. Copyright (C) 2001 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 08:53:06