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Titolo:
Pharmacological control of platelet function
Autore:
Clutton, P; Folts, JD; Freedman, JE;
Indirizzi:
Georgetown Univ, Med Ctr, Dept Med & Pharmacol, Washington, DC 20007 USA Georgetown Univ Washington DC USA 20007 armacol, Washington, DC 20007 USA Univ Wisconsin, Madison, WI USA Univ Wisconsin Madison WI USAUniv Wisconsin, Madison, WI USA
Titolo Testata:
PHARMACOLOGICAL RESEARCH
fascicolo: 4, volume: 44, anno: 2001,
pagine: 255 - 264
SICI:
1043-6618(200110)44:4<255:PCOPF>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLYCOPROTEIN-IIB/IIIA RECEPTOR; VONWILLEBRAND-FACTOR BINDING; MURINE MONOCLONAL-ANTIBODY; ARACHIDONIC-ACID LIBERATION; PROSTAGLANDIN-G/H SYNTHASE; VON-WILLEBRAND-FACTOR; GP-IIB-IIIA; NONHUMAN-PRIMATES; ADP RECEPTORS; CORONARY-THROMBOSIS;
Keywords:
platelets; thrombosis; aspirin; glycoprotein IIb/IIIa; platelet inhibitors;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
136
Recensione:
Indirizzi per estratti:
Indirizzo: Freedman, JE Georgetown Univ, Med Ctr, Dept Med & Pharmacol, 3900 Reservoir Rd NW, Washington, DC 20007 USA Georgetown Univ 3900 Reservoir Rd NW Washington DC USA 20007
Citazione:
P. Clutton et al., "Pharmacological control of platelet function", PHARMAC RES, 44(4), 2001, pp. 255-264

Abstract

Advancement in the understanding of the mechanisms of platelet activation,as well as the development of new techniques for studying platelet function, have led to the availability of new classes of platelet inhibiting drugs. Initially, characterization of arachidonic acid metabolism in platelets furthered an understanding of the utility of cyclooxygenase inhibitors, mostnotably aspirin. The discovery and characterization of platelet receptors such as the adenosine diphosphate (ADP) receptor and glycoprotein IIb/IIIa has been associated with the development of novel classes of anti-platelet drug, such as thienopyridine derivatives and glycoprotein IIb/IIIa receptorantagonists, respectively. Future development in receptor pathway inhibitors also includes glycoprotein Ib/IX as well as the potential use of platelet signaling pathway inhibitors. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/01/20 alle ore 12:23:44