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Titolo:
Antiepileptic drugs: Affective use in autism spectrum disorders
Autore:
Di Martino, A; Tuchman, RF;
Indirizzi:
Miami Childrens Hosp, Dept Neurol, Dan Marino Ctr, Weston, FL 33331 USA Miami Childrens Hosp Weston FL USA 33331 Marino Ctr, Weston, FL 33331 USA Univ Cagliari, Dept Neurosci Child Neurol & Psychiat, Cagliari, Italy UnivCagliari Cagliari Italy i Child Neurol & Psychiat, Cagliari, Italy
Titolo Testata:
PEDIATRIC NEUROLOGY
fascicolo: 3, volume: 25, anno: 2001,
pagine: 199 - 207
SICI:
0887-8994(200109)25:3<199:ADAUIA>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
GAMMA-AMINOBUTYRIC-ACID; PERVASIVE DEVELOPMENTAL DISORDER; FOCAL INTERICTAL SPIKES; EPILEPSY-PRONE RATS; INFANTILE-AUTISM; VALPROIC ACID; PLASMA GABA; ANTICONVULSANT DRUGS; NEUROPSYCHIATRIC DISORDERS; SEROTONIN CONCENTRATION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
120
Recensione:
Indirizzi per estratti:
Indirizzo: Tuchman, RF Miami Childrens Hosp, Dept Neurol, Dan Marino Ctr, 2900 S Commerce Pkwy, Weston, FL 33331 USA Miami Childrens Hosp 2900 S Commerce Pkwy Weston FL USA 33331
Citazione:
A. Di Martino e R.F. Tuchman, "Antiepileptic drugs: Affective use in autism spectrum disorders", PED NEUROL, 25(3), 2001, pp. 199-207

Abstract

Antiepileptic drugs are widely administered to individuals with autistic spectrum disorders. There are several reasons for the use of antiepileptic drugs in autistic spectrum disorders, including the high incidence of epilepsy in these individuals, the anecdotal reports suggesting an improvement ofcommunication and behavior in autistic subjects with epileptic discharges,and the increased awareness that some disruptive behaviors may be manifestations of an associated affective disorder. In this study, data on the current use of antiepileptic drugs in the treatment of autism, and on the association of affective disorders with epilepsy and autism, are reviewed. The evidence supporting the hypothesis that there may be a subgroup of autistic children with epilepsy and affective disorders that preferentially respond to antiepileptic drugs is still very preliminary, and further investigations with double-blind controlled studies are needed. Although the role of antiepileptic drugs at the present time is not established, there is evidence that autism, epilepsy, and affective disorders commonly co-occur, and that they may share a common neurochemical substrate, which is the common targetof the psychotropic mechanism of action of different antiepileptic drugs. (C) 2001 by Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 01:47:09