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Titolo:
Basal ganglia dysfunction in Tourette's syndrome: A new hypothesis
Autore:
Mink, JW;
Indirizzi:
Washington Univ, Sch Med, Dept Neurol, St Louis, MO 63110 USA Washington Univ St Louis MO USA 63110 Dept Neurol, St Louis, MO 63110 USA Washington Univ, Sch Med, Dept Anat & Neurobiol, St Louis, MO 63110 USA Washington Univ St Louis MO USA 63110 & Neurobiol, St Louis, MO 63110 USA Washington Univ, Sch Med, Dept Pediat, St Louis, MO 63110 USA Washington Univ St Louis MO USA 63110 Dept Pediat, St Louis, MO 63110 USA
Titolo Testata:
PEDIATRIC NEUROLOGY
fascicolo: 3, volume: 25, anno: 2001,
pagine: 190 - 198
SICI:
0887-8994(200109)25:3<190:BGDITS>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRIMATE GLOBUS PALLIDUS; SUBTHALAMIC NUCLEUS; SPATIAL-ORGANIZATION; FUNCTIONAL-ANATOMY; DOPAMINE-RECEPTORS; PREFRONTAL CORTEX; SUBSTANTIA NIGRA; RAT NEOSTRIATUM; SQUIRREL-MONKEY; SPINY NEURONS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
86
Recensione:
Indirizzi per estratti:
Indirizzo: Mink, JW Washington Univ, Sch Med, Dept Neurol, Box 8111,660 S Euclid Ave,St Louis, MO 63110 USA Washington Univ Box 8111,660 S Euclid Ave St Louis MO USA 63110 A
Citazione:
J.W. Mink, "Basal ganglia dysfunction in Tourette's syndrome: A new hypothesis", PED NEUROL, 25(3), 2001, pp. 190-198

Abstract

Tourette's syndrome is a neuropsychiatric syndrome with onset in childhoodthat is characterized by chronic multiple ties. The cause of Tourette's syndrome is unknown, but the pathophysiology most likely involves basal ganglia and frontocortical circuits. A useful scheme of basal ganglia dysfunction should be able to account for the features that make Tourette's syndrome unique, in addition to the features that Tourette's syndrome shares with other disorders. Recent advances in knowledge of basal ganglia functional anatomy and physiology make it possible to hypothesize how specific neural mechanisms relate to specific clinical manifestations of Tourette's syndrome. A model of selection and suppression of competing behaviors by the basal ganglia is presented. The functional anatomy of basal ganglia circuits and new information on dopamine modulation of those circuits provide the basis for hypotheses of basal ganglia dysfunction in Tourette's syndrome. (C) 2001 by Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 06:22:14