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Titolo:
QT prolongation associated with azithromycin/amiodarone combination
Autore:
Samarendra, P; Kumari, S; Evans, SJ; Sacchi, TJ; Navarro, V;
Indirizzi:
Long Isl Coll Hosp, Dept Cardiol, Brooklyn, NY 11201 USA Long Isl Coll Hosp Brooklyn NY USA 11201 Cardiol, Brooklyn, NY 11201 USA Beth Israel Med Ctr, Electrophysiol Lab, New York, NY 10003 USA Beth Israel Med Ctr New York NY USA 10003 iol Lab, New York, NY 10003 USA
Titolo Testata:
PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY
fascicolo: 10, volume: 24, anno: 2001,
pagine: 1572 - 1574
SICI:
0147-8389(200110)24:10<1572:QPAWAC>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
TORSADE-DE-POINTES; AMIODARONE; ERYTHROMYCIN; DISPERSION; INTERVAL;
Keywords:
QT interval; QT dispersion; azithromycin; torsades de pointes; erythromycin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
12
Recensione:
Indirizzi per estratti:
Indirizzo: Samarendra, P 86 Baltic St,Apt 3, Brooklyn, NY 11201 USA 86 Baltic St,Apt3 Brooklyn NY USA 11201 klyn, NY 11201 USA
Citazione:
P. Samarendra et al., "QT prolongation associated with azithromycin/amiodarone combination", PACE, 24(10), 2001, pp. 1572-1574

Abstract

Administration of oral azithromycin, in addition to previously well-tolerated long-term amiodarone therapy, was associated with a marked prolongationof QT interval and increased QT dispersion, both substrates for life-threatening ventricular tachyarrhythmia and torsades de pointes. This is a report of QT prolongation and increased QT dispersion associated with the use ofazithromycin. The report assumes an added significance, in view of widespread empirical use of this antibiotic for the treatment of lower respiratoryinfections and belief of its safety in patients with cardiac diseases. Based on the authors' experience, they would like to emphasize that the combination of azithromycin with other drugs known to prolong QT or causing torsades de pointes be used with caution until the question of the proarrhythmiceffect of azithromycin is resolved by further studies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 19:43:57