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Titolo:
Functions of the adapter protein Cas: signal convergence and the determination of cellular responses
Autore:
Bouton, AH; Riggins, RB; Bruce-Staskal, PJ;
Indirizzi:
Univ Virginia, Hlth Sci Ctr, Dept Microbiol, Charlottesville, VA 22908 USAUniv Virginia Charlottesville VA USA 22908 Charlottesville, VA 22908 USA
Titolo Testata:
ONCOGENE
fascicolo: 44, volume: 20, anno: 2001,
pagine: 6448 - 6458
SICI:
0950-9232(20011001)20:44<6448:FOTAPC>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
FOCAL ADHESION KINASE; CRK-ASSOCIATED SUBSTRATE; PHOSPHOTYROSINE-CONTAINING PROTEINS; NUCLEOTIDE EXCHANGE FACTOR; HUMAN BREAST-CANCER; DEPENDENT TYROSINE PHOSPHORYLATION; JUN NH2-TERMINAL KINASE; PHOSPHATASE PTP-PEST; SRC FAMILY KINASES; GROWTH-FACTOR;
Keywords:
Cas; Src; Crk; Rac1; migration; adapter;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
136
Recensione:
Indirizzi per estratti:
Indirizzo: Bouton, AH Univ Virginia, Hlth Sci Ctr, Dept Microbiol, Box 800734, Charlottesville, VA 22908 USA Univ Virginia Box 800734 Charlottesville VA USA 22908 22908 USA
Citazione:
A.H. Bouton et al., "Functions of the adapter protein Cas: signal convergence and the determination of cellular responses", ONCOGENE, 20(44), 2001, pp. 6448-6458

Abstract

Since Cas was first identified as a highly phosphorylated 130 kilodalton protein that associated with the v-Src and v-Crk-oncoproteins, considerable effort has been made to determine its function. Its predicted role as a scaffolding molecule based on its domain structure has been largely confirmed. Through its ability to undergo rapid changes in phosphorylation, subcellular localization and association with heterologous proteins, Cas may spatially and temporally regulate the function of its binding partners. Numerous proteins have been identified that bind to Cas in vitro and/or in vivo, but in only a few cases is there an understanding of how Cas may function in these protein complexes. To date, Cas-Crk and Cas-Src complexes have been most frequently implicated in Cas function, particularly in regards to processes involving regulation of the actin cytoskeleton and proliferation. These and other Cas protein complexes contribute to the critical role of Cas in cell adhesion, migration, proliferation and survival of normal cycling cells. However, under conditions in which these processes are deregulated, Cas appears to play a role in oncogenic transformation and perhaps metastasis. Therefore, in its capacity as an adapter protein, Cas serves as a point of convergence for many distinct signaling inputs, ultimately contributing to the generation of specific cellular responses.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 01:13:54