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Titolo:
Mammary epithelial-specific expression of the integrin linked kinase (ILK)results in the induction of mammary gland hyperplasias and tumors in transgenic mice
Autore:
White, DE; Cardiff, RD; Dedhar, S; Muller, WJ;
Indirizzi:
McMaster Univ, MOBIX, Hamilton, ON L8S 4K1, Canada McMaster Univ HamiltonON Canada L8S 4K1 IX, Hamilton, ON L8S 4K1, Canada McMaster Univ, Dept Med Sci, Hamilton, ON L8S 4K1, Canada McMaster Univ Hamilton ON Canada L8S 4K1 ci, Hamilton, ON L8S 4K1, Canada Univ Calif Davis, Ctr Comparat Med, Davis, CA 95616 USA Univ Calif Davis Davis CA USA 95616 Ctr Comparat Med, Davis, CA 95616 USA British Columbia Canc Agcy, Jack Bell Res Ctr, Vancouver, BC V6H 3Z6, Canada British Columbia Canc Agcy Vancouver BC Canada V6H 3Z6 BC V6H 3Z6, Canada Univ British Columbia, Dept Biochem & Mol Biol, Vancouver, BC V6H 3Z6, Canada Univ British Columbia Vancouver BC Canada V6H 3Z6 ver, BC V6H 3Z6, Canada McMaster Univ, Dept Pathol & Mol Med, Hamilton, ON L8S 4K1, Canada McMaster Univ Hamilton ON Canada L8S 4K1 ed, Hamilton, ON L8S 4K1, Canada
Titolo Testata:
ONCOGENE
fascicolo: 48, volume: 20, anno: 2001,
pagine: 7064 - 7072
SICI:
0950-9232(20011025)20:48<7064:MEEOTI>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLYCOGEN-SYNTHASE KINASE-3; AP-1 TRANSCRIPTION FACTOR; PROTEIN-KINASE; SIGNALING PATHWAYS; CELL-ADHESION; PHENOTYPE; PROGRESSION; INHIBITION; RECEPTORS; B/AKT;
Keywords:
integrin linked kinase; ILK; transgenic mice; mammary epithelium; breast cancer; tumorigenesis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Muller, WJ McMaster Univ, MOBIX, 1280 Main St W, Hamilton, ON L8S 4K1, Canada McMaster Univ 1280 Main St W Hamilton ON Canada L8S 4K1 Canada
Citazione:
D.E. White et al., "Mammary epithelial-specific expression of the integrin linked kinase (ILK)results in the induction of mammary gland hyperplasias and tumors in transgenic mice", ONCOGENE, 20(48), 2001, pp. 7064-7072

Abstract

The integrin linked kinase (ILK) is a cytoplasmic effector of integrin receptors, involved in the regulation of integrin binding properties as well as the activation of cell survival and proliferative pathways, including those involving MAP kinase, PKB/Akt and GSK-3 beta. Overexpression of ILK in cultured intestinal and mammary epithelial cells has been previously shown to induce changes characteristic of oncogenic transformation, including anchorage-independent growth, invasiveness, suppression of anoikis and tumorigenicity in nude mice. In order to determine if ILK overexpression can resultin the formation of mammary tumors in vivo, we generated transgenic mice expressing ILK in the mammary epithelium, under the transcriptional control of the mouse mammary tumor virus (MMTV) long terminal repeat (LTR). By the age of 6 months, female MMTV/ILK mice developed a hyperplastic mammary phenotype, which was accompanied by the constitutive phosphorylation of PKB/Akt, GSK-3 beta and MAP kinase. Focal mammary tumors subsequently appeared in 34% of the animals at an average age of 18 months. Given the focal nature and long latency of the tumors, however, additional genetic events are likely required for tumor induction in the MMTV/ILK mice. These results provide the first direct demonstration of a potential oncogenic role for ILK, whichis upregulated in human tumors and tumor cell lines.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/10/20 alle ore 08:28:30