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Titolo:
Urinary 1-hydroxypyrene in coke oven workers relative to exposure, alcoholconsumption, and metabolic enzymes
Autore:
Zhang, J; Ichiba, M; Hara, K; Zhang, S; Hanaoka, T; Pan, G; Yamano, Y; Takahashi, K; Tomokuni, K;
Indirizzi:
Saga Med Sch, Dept Community Hlth Sci, Saga 8498501, Japan Saga Med Sch Saga Japan 8498501 Community Hlth Sci, Saga 8498501, Japan Inst Sci & Labour, Miyamae Ku, Kawasaki, Kanagawa 2168501, Japan Inst Sci & Labour Kawasaki Kanagawa Japan 2168501 Kanagawa 2168501, Japan Liaoning Publ Hlth Antiepidem Stn, Shenyang 110005, Peoples R China Liaoning Publ Hlth Antiepidem Stn Shenyang Peoples R China 110005 China Natl Canc Res Inst E, Epidemiol & Biostat Div, Kashiwa, Chiba 2778577, Japan Natl Canc Res Inst E Kashiwa Chiba Japan 2778577 wa, Chiba 2778577, Japan Tokyo Womens Med Univ, Shinjuku Ku, Tokyo 1628666, Japan Tokyo Womens Med Univ Tokyo Japan 1628666 njuku Ku, Tokyo 1628666, Japan Univ Occupat & Environm Hlth, Yahatanishi Ku, Kitakyushu, Fukuoka 8078555,Japan Univ Occupat & Environm Hlth Kitakyushu Fukuoka Japan 8078555 78555,Japan
Titolo Testata:
OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
fascicolo: 11, volume: 58, anno: 2001,
pagine: 716 - 721
SICI:
1351-0711(200111)58:11<716:U1ICOW>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYCYCLIC AROMATIC-HYDROCARBONS; LUNG-CANCER; GENETIC-POLYMORPHISM; CYP1A1 GENOTYPES; LIFE-STYLE; EXCRETION; IDENTIFICATION; SUSCEPTIBILITY; CARCINOGENS; JAPANESE;
Keywords:
1-hydroxypyrene; genetic polymorphism; alcohol drinking;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Zhang, J Saga Med Sch, Dept Community Hlth Sci, Saga 8498501, Japan Saga Med Sch Saga Japan 8498501 y Hlth Sci, Saga 8498501, Japan
Citazione:
J. Zhang et al., "Urinary 1-hydroxypyrene in coke oven workers relative to exposure, alcoholconsumption, and metabolic enzymes", OCC ENVIR M, 58(11), 2001, pp. 716-721

Abstract

Objectives-To investigate the influence of personal lifestyle-such as smoking and alcohol consumption-on urinary 1-hydroxypyrene (1-OHP) concentrations in coke oven workers exposed to polycyclic aromatic hydrocarbons (PAHs) and to evaluate the association of 1-OHP concentrations with the genetic polymorphism of several metabolic enzymes including cytochrome P-450 (CYP) 1A1 and glutathione S-tranferases (GSTs). Methods-The study population contained 162 coke oven workers and 5S controls employed at the largest iron and steel factory in China. Personal data were collected at the interview. 1-OHP in urine was measured with high performance liquid chromatography with fluorescence detection. Genetic polymorphisms were identified by the polymerase chain reaction (PCR) method. Results-A positive association between excretion of urinary 1-OHP and the levels of exposure to PAHs was confirmed. Those people who consumed greaterthan or equal to 50 g/day ethanol had significantly higher 1-OHP excretionthan did other coke oven workers (p <0.01). No significant difference in urinary 1-OHP was found between smokers and non-smokers, in both controls and exposed subjects. The variant homozygotes at exon 7 of the CYP1A1 gene had significantly higher urinary 1-OHP concentrations than other CYP1A1 genotypes among the exposed workers (p=0.03). There was less association betweenthe concentrations of 1-OHP and the GSTM1, GSTP1, or GSTT1 polymorphism. Conclusions-The present study confirmed that urinary 1-ORP is a good biomarker for exposure to PAHs. Alcohol consumption affected urinary 1-OHP excretion. The variant genotypes of the CYP1A1 gene may result in the enhancement of PAR metabolites. It is helpful to understand the role of individual susceptibility on metabolism of carcinogens. These findings suggest that the modulating effect of individual lifestyle factors or genetic nature should be considered in future studies on occupational exposure to PAHs and in evaluating the health risk from harmful chemicals.

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Documento generato il 02/04/20 alle ore 07:40:14