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Titolo:
Influence of leptin on changes in body fat during growth in African American and white children
Autore:
Johnson, MS; Huang, TTK; Figueroa-Colon, R; Dwyer, JH; Goran, MI;
Indirizzi:
Univ So Calif, Dept Prevent Med, Inst Hlth Promot & Dis Prevent Res, Los Angeles, CA 90033 USA Univ So Calif Los Angeles CA USA 90033 ent Res, Los Angeles, CA 90033 USA Mead Johnson Nutrit, Evansville, IN USA Mead Johnson Nutrit Evansville INUSA Johnson Nutrit, Evansville, IN USA
Titolo Testata:
OBESITY RESEARCH
fascicolo: 10, volume: 9, anno: 2001,
pagine: 593 - 598
SICI:
1071-7323(200110)9:10<593:IOLOCI>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
X-RAY ABSORPTIOMETRY; SERUM LEPTIN; WEIGHT-GAIN; CROSS-CALIBRATION; ADIPOSE-TISSUE; PUBERTY; WOMEN; EXPRESSION; RESISTANCE; HUMANS;
Keywords:
leptin; children; body fat; longitudinal; ethnicity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Goran, MI Univ So Calif, Dept Prevent Med, Inst Hlth Promot & Dis Prevent Res, 1540 Alcazar St,Room 208, Los Angeles, CA 90033 USA Univ So Calif 1540Alcazar St,Room 208 Los Angeles CA USA 90033
Citazione:
M.S. Johnson et al., "Influence of leptin on changes in body fat during growth in African American and white children", OBES RES, 9(10), 2001, pp. 593-598

Abstract

Objective: The aim of this study was to determine whether initial levels or temporal changes in fasting leptin were associated with longitudinal changes in body-fat mass in children. Research Methods and Procedures: The study group consisted of 85 children (42 white and 43 African American) with a mean initial age of 8.1 +/- 0.1 years. The children had between three and six annual visits for repeated measurements of body composition by DXA and fasting leptin level. Fat mass andfasting leptin level were not normally distributed and were loo-transformed. Data were analyzed using SAS Proc mixed growth models, with log fat as the dependent variable. Results: Initial leptin level was a significant predictor of the change infat mass over time (p < 0.0001), with high initial leptin levels resultingin increased fat gain, independent of initial fat levels. This relationship remained significant when the data were analyzed separately by race (whites, p < 0.0001; African Americans, p = 0.008). The relationship between theinitial level of leptin and the change in fat mass was not modified by race, sex, or Tanner Stage. The rate of change in leptin during the study was significantly related to the rate of change in fat mass in African Americans (p 0.008) but not in whites (p = 0.490). Discussion: In conclusion, high fasting leptin level at the start of the study was significantly associated with increasing fat mass in this cohort, indicating that the children may be developing resistance to the effects ofleptin.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 20:20:14