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Titolo:
Renal actions of the alpha(2)-adrenoceptor agonist, xylazine, in the anaesthetised rat
Autore:
Miller, JH; McCoy, KD; Colman, AS;
Indirizzi:
Univ Victoria, Sch Biol Sci, Wellington, New Zealand Univ Victoria Wellington New Zealand Biol Sci, Wellington, New Zealand Inst Expt Immunol, CH-8091 Zurich, Switzerland Inst Expt Immunol Zurich Switzerland CH-8091 CH-8091 Zurich, Switzerland
Titolo Testata:
NEW ZEALAND VETERINARY JOURNAL
fascicolo: 5, volume: 49, anno: 2001,
pagine: 173 - 180
SICI:
0048-0169(200110)49:5<173:RAOTAA>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
CLONIDINE-INDUCED DIURESIS; ALPHA-2-ADRENOCEPTOR AGONISTS; ANESTHETIZED RATS; INSULIN RELEASE; HYPERGLYCEMIA; VASOPRESSIN; NERVES; WATER; INHIBITION; ANESTHESIA;
Keywords:
alpha-2 adrenoceptors; clonidine; glomerular filtration rate; kidney; oxymetazoline; prazosin; rat; vasopressin; xylazine; yohimbine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Miller, JH Univ Victoria, Sch Biol Sci, Wellington, New Zealand Univ Victoria Wellington New Zealand Wellington, New Zealand
Citazione:
J.H. Miller et al., "Renal actions of the alpha(2)-adrenoceptor agonist, xylazine, in the anaesthetised rat", NZ VET J, 49(5), 2001, pp. 173-180

Abstract

AIMS: The aims of the present study were to characterise the renal effectsof the alpha (2)-adrenergic agonist, xylazine, in the rat and to test the role of changes in glomerular filtration rate, glucosuria, and arginine vasopressin (AVP) in its mechanism of action. METHODS: Male Wistar rats were anaesthetised with pentobarbitone sodium (50 mg/kg), and polyethylene cannulae were surgically placed for blood pressure measurement and for blood and urine collection. Rats were given xylazineand other alpha (2) agonists by bolus intravenous dose, and the effects ofthe drugs were monitored in the presence and absence of the selective alpha (2) antagonist, yohimbine, the alpha (1),alpha (2), antagonist, prazosin,and the V-2-receptor antagonist, d(CH2)(5) [D-Ile(2),Ile(4),Ala-NH29]AVP. RESULTS: Xylazine at 2.5 mg/kg caused a significant and prolonged dose-dependent increase in urine flow rate and sodium excretion but had only short-lasting effects on blood pressure, heart rate, and glomerular filtration rate. Prazosin had no effect on the measured responses. Although plasma glucose concentration and glucose excretion rate were increased by xylazine, themagnitudes of these increases were insufficient to account for the diuresis observed. Xylazine, and 2 other a(2) agonists, clonidine and oxymetazoline, increased urine flow and/or sodium excretion despite the presence of d(CH2)(5) [D-Ile(2),Ile(4) Ala-NH29] AVP. CONCLUSIONS: Xylazine causes a diuretic and natriuretic alpha (2A)-adrenergic response in the rat that is independent of changes in glomerular filtration rate, the development of glucosuria, or AVP action on the distal nephron of the kidneys. CLINICAL RELEVANCE: The adverse effects of xylazine on salt and water balance need to be considered and possibly compensated for by fluid replacementor post-surgical administration of alpha (2)-receptor antagonists.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 18:36:52