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Titolo:
Autoradiographic mapping of the opioid receptor-like 1 (ORL1) receptor in the brains of mu-, delta- or kappa-opioid receptor knockout mice
Autore:
Slowe, SJ; Clarke, S; Lena, I; Goody, RJ; Lattanzi, R; Negri, L; Simonin, F; Matthes, HWD; Filliol, D; Kieffer, BL; Kitchen, I;
Indirizzi:
Univ Surrey, Sch Biomed & Life Sci, Pharmacol Grp, Guildford GU2 7XH, Surrey, England Univ Surrey Guildford Surrey England GU2 7XH ord GU2 7XH, Surrey, England Univ Strasbourg 1, ESBS, UPR 9050 CNRS, F-67400 Strasbourg, France Univ Strasbourg 1 Strasbourg France F-67400 , F-67400 Strasbourg, France CHU Grenoble, INSERM U318, F-38043 Grenoble, France CHU Grenoble Grenoble France F-38043 SERM U318, F-38043 Grenoble, France Univ Roma La Sapienza, Dept Human Physiol & Pharmacol, I-00185 Rome, ItalyUniv Roma La Sapienza Rome Italy I-00185 Pharmacol, I-00185 Rome, Italy
Titolo Testata:
NEUROSCIENCE
fascicolo: 3, volume: 106, anno: 2001,
pagine: 469 - 480
SICI:
0306-4522(2001)106:3<469:AMOTOR>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUPRASPINAL ORPHANIN FQ/NOCICEPTIN; MORPHINE-INDUCED ANALGESIA; MESSENGER-RNA LEVELS; NOCICEPTIN/ORPHANIN FQ; NUCLEUS-ACCUMBENS; DOPAMINE RELEASE; LACKING; RATS; GENE; BINDING;
Keywords:
ORL1 receptor; opioid receptors; knockout mice; autoradiography; transgenic;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Kitchen, I Univ Surrey, Sch Biomed & Life Sci, Pharmacol Grp, Guildford GU2 7XH, Surrey, England Univ Surrey Guildford Surrey England GU2 7XH , Surrey, England
Citazione:
S.J. Slowe et al., "Autoradiographic mapping of the opioid receptor-like 1 (ORL1) receptor in the brains of mu-, delta- or kappa-opioid receptor knockout mice", NEUROSCIENC, 106(3), 2001, pp. 469-480

Abstract

The opioid receptor-like 1 (ORL1) receptor shares a high degree of sequence homology with the classical mu-, delta- and kappa -opioid receptors and afunctional mutual opposition between these receptors has been suggested, To further address this possible interaction we have used mu-, delta- and kappa -opioid receptor knockout mice to determine autoradiographically if there are any changes in the number or distribution of the ORL1 receptor, labelled with [H-3]nociceptin, in the brains of mice deficient in each of the opioid receptors. An up-regulation of ORL1 expression was observed across all brain regions in delta -knockouts with cortical regions typically showinga 15-30% increase in binding that was most marked in heterozygous mice. Incontrast, ORL1 receptor expression was down-regulated in virtually all brain structures in heterozygous kappa -knockouts although the magnitude of this change was not as great as for the delta -knockouts. No significant alterations in ORL1 receptor expression were observed across brain regions in delta -receptor knockout mice and there were no qualitative differences in ORL1 receptor expression in any groups. These data suggest there are interactions between the ORL1 system and the classical opioid receptors and that the interactions are receptor-specific,The greater differences observed in heterozygous mice suggest that these interactions might be most relevant when there is only partial loss of receptor function. (C) 2001 IBRO. Published by Elsevier Science Ltd. All rights reserved.

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Documento generato il 26/01/20 alle ore 09:53:44