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Titolo:
The effects of APOE genotype on age at onset and progression of neurodegenerative diseases
Autore:
Chapman, J; Korczyn, AD; Karussis, DM; Michaelson, DM;
Indirizzi:
Tel Aviv Univ, George S Wise Fac Life Sci, Dept Neurobiochem, IL-69789 TelAviv, Israel Tel Aviv Univ Tel Aviv Israel IL-69789 biochem, IL-69789 TelAviv, Israel Tel Aviv Univ, Sackler Fac Med, Dept Physiol & Pharmacol, IL-69978 Tel Aviv, Israel Tel Aviv Univ Tel Aviv Israel IL-69978 rmacol, IL-69978 Tel Aviv, Israel Tel Aviv Univ, Sackler Fac Med, Dept Neurol, IL-69978 Tel Aviv, Israel TelAviv Univ Tel Aviv Israel IL-69978 Neurol, IL-69978 Tel Aviv, Israel Hadassah Med Ctr, Dept Neurol, IL-91120 Jerusalem, Israel Hadassah Med Ctr Jerusalem Israel IL-91120 l, IL-91120 Jerusalem, Israel
Titolo Testata:
NEUROLOGY
fascicolo: 8, volume: 57, anno: 2001,
pagine: 1482 - 1485
SICI:
0028-3878(20011023)57:8<1482:TEOAGO>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
APOLIPOPROTEIN-E EPSILON-4; AMYOTROPHIC-LATERAL-SCLEROSIS; TRAUMATIC BRAIN INJURY; MOTOR-NEURON DISEASE; AMYLOID BETA-PROTEIN; E TYPE-4 ALLELE; ALZHEIMERS-DISEASE; MULTIPLE-SCLEROSIS; COGNITIVE DECLINE; E POLYMORPHISM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
58
Recensione:
Indirizzi per estratti:
Indirizzo: Michaelson, DM Tel Aviv Univ, George S Wise Fac Life Sci, Dept Neurobiochem, IL-69789 TelAviv, Israel Tel Aviv Univ Tel Aviv Israel IL-69789 89 TelAviv, Israel
Citazione:
J. Chapman et al., "The effects of APOE genotype on age at onset and progression of neurodegenerative diseases", NEUROLOGY, 57(8), 2001, pp. 1482-1485

Abstract

APOE genotype influences the age at onset of some neurodegenerative diseases such as AD and the rate of progression in others such as MS. The authorshypothesize that APOE genotype ubiquitously determines the efficacy of neuronal maintenance and repair in these diseases and that the seemingly divergent clinical effects are due to the stage of disease at which the diagnosis is made. Early diagnosis facilitates the measurement of effects on disease progression rate, whereas late diagnosis results in a marked effect of APOE genotype on disease onset.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 09:28:59