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Titolo:
Cholesterol and neuropathologic markers of AD - A population-based autopsystudy
Autore:
Launer, LJ; White, LR; Petrovitch, H; Ross, GW; Curb, JD;
Indirizzi:
NIA, EDBP, Lab Epidemiol Demog & Biometry, NIH, Bethesda, MD 20892 USA NIA Bethesda MD USA 20892 l Demog & Biometry, NIH, Bethesda, MD 20892 USA Pacific Hlth Res Inst, Honolulu, HI USA Pacific Hlth Res Inst Honolulu HIUSA ic Hlth Res Inst, Honolulu, HI USA Dept Vet Adm Honolulu, Honolulu, HI USA Dept Vet Adm Honolulu Honolulu HIUSA Vet Adm Honolulu, Honolulu, HI USA Kuakini Med Ctr, Honolulu Heart Program, Honolulu, HI 96817 USA Kuakini Med Ctr Honolulu HI USA 96817 art Program, Honolulu, HI 96817 USA Univ Hawaii, John A Burns Sch Med, Dept Med, Honolulu, HI 96822 USA Univ Hawaii Honolulu HI USA 96822 h Med, Dept Med, Honolulu, HI 96822 USA
Titolo Testata:
NEUROLOGY
fascicolo: 8, volume: 57, anno: 2001,
pagine: 1447 - 1452
SICI:
0028-3878(20011023)57:8<1447:CANMOA>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMYLOID-BETA-PEPTIDE; DENSITY-LIPOPROTEIN CHOLESTEROL; APOLIPOPROTEIN-E GENOTYPE; JAPANESE-AMERICAN MEN; ALZHEIMERS-DISEASE; PRECURSOR PROTEIN; BLOOD-PRESSURE; APOE GENOTYPE; HUMAN BRAIN; DEMENTIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Launer, LJ NIA, EDBP, Lab Epidemiol Demog & Biometry, NIH, Gateway Bldg 3C-309,7201 Wisconsin Ave, Bethesda, MD 20892 USA NIA Gateway Bldg 3C-309,7201 Wisconsin Ave Bethesda MD USA 20892
Citazione:
L.J. Launer et al., "Cholesterol and neuropathologic markers of AD - A population-based autopsystudy", NEUROLOGY, 57(8), 2001, pp. 1447-1452

Abstract

Objective: To examine the association of plasma cholesterol (total and high-density [HDL] and low-density lipoprotein) levels with neuritic plaques (NP) and neurofibrillary tangles (NFT) in a population-based autopsy series of 218 Japanese American men followed as a part of the Honolulu-Asia Aging Study. Methods: Cholesterol levels were measured in late life (average age at death 84.6 years) in all subjects (n = 218) and in midlife (20 years before late life) in a subsample (n = 89); for the analyses, levels were categorized into quintiles, with the lowest quintile serving as the reference. Tissue from four areas of neocortex and two areas of hippocampus was prepared with Bielschowsky silver-stained sections and evaluated by one of three neuropathologists who were blinded to clinical information. Diffuse and neuritic plaques and NFT were counted in field areas standardized to 1 mm(2). Fields were selected from areas with the highest numbers of lesions, and thefield with the highest count was taken to represent the brain area. Results: After adjusting for age at death, education, APOE allele, dementia, neuropathologic infarction, and blood pressure, a strong linear association wasfound for increasing late-life HDL cholesterol (HDL-C) levels and an increasing number of neocortical NP (5th versus 1st quintile: count ratio [95% CI] 2.30 [1.05 to 5.06]) and hippocampal (2.63 [1.25 to 5.50]) and neocortical (4.20 [1.73 to 10.16]) NFT. Trends were similar for the midlife HDL-C levels. Conclusions: The constituents of HDL-C may play a role in the formation of AD pathology, and these processes are reflected in peripheral measures.

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Documento generato il 01/12/20 alle ore 16:42:28