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Titolo:
Ionizing radiation does not alter the antitumor activity of herpes simplexvirus vector G207 in subcutaneous tumor models of human and murine prostate cancer
Autore:
Jorgensen, TJ; Katz, S; Wittmack, EK; Varghese, S; Todo, T; Rabkin, SD; Martuza, RL;
Indirizzi:
Georgetown Univ, Med Ctr, Dept Radiat Med, Vincent T Lombardi Canc Res Ctr, Washington, DC 20007 USA Georgetown Univ Washington DC USA 20007 Res Ctr, Washington, DC 20007 USA Georgetown Univ, Med Ctr, Dept Biochem & Mol Biol, Vincent T Lombardi CancRes Ctr, Washington, DC 20007 USA Georgetown Univ Washington DC USA 20007 Res Ctr, Washington, DC 20007 USA Georgetown Univ, Med Ctr, Dept Neurosurg, Vincent T Lombardi Canc Res Ctr,Washington, DC 20007 USA Georgetown Univ Washington DC USA 20007 Res Ctr,Washington, DC 20007 USA
Titolo Testata:
NEOPLASIA
fascicolo: 5, volume: 3, anno: 2001,
pagine: 451 - 456
SICI:
1522-8002(200109/10)3:5<451:IRDNAT>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
REPLICATION-COMPETENT; MALIGNANT GLIOMA; RECURRENT HEAD; NECK-CANCER; PHASE-I; CELLS; THERAPY; ADENOVIRUS; APOPTOSIS; ONYX-015;
Keywords:
herpes virus; gene therapy; prostate cancer; radiotherapy; oncolytic virus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Jorgensen, TJ Georgetown Univ, Med Ctr, Dept Radiat Med, Vincent T Lombardi Canc Res Ctr, TRB Room E212A,3970 Reservoir Rd, Washington, DC 20007 USA Georgetown Univ TRB Room E212A,3970 Reservoir Rd Washington DC USA 20007
Citazione:
T.J. Jorgensen et al., "Ionizing radiation does not alter the antitumor activity of herpes simplexvirus vector G207 in subcutaneous tumor models of human and murine prostate cancer", NEOPLASIA, 3(5), 2001, pp. 451-456

Abstract

Viral gene therapy against malignant tumors holds great promise for tumorsthat are susceptible to the oncolytic activity of viruses. One advantage of oncolytic viral therapy is that it can potentially be combined with othertherapies, such as radiotherapy, to obtain an enhanced tumor response. In the case of prostate cancer, herpes simplex virus-mediated therapies have been shown to be highly effective in animal models; however, studies of the efficacy of combined viral and radiation therapy have not yet been reported. In this study, we have combined G207, a multimutated HSV type 1 vector, with external beam radiation therapy of prostate tumors grown subcutaneouslyin mice. We examined both the human LNCaP tumor in athymic mice and the mouse transgenic TRAMP tumor in either athymic mice or its syngeneic host, C57BL/6 mice. Virus was delivered either intravenously, in the case of LNCaP,or intratumorally, in the case of TRAMP. We found that individually, either G207 or radiation was effective in delaying tumor growth in these models. However, delivering the treatments simultaneously did not produce an enhanced effect.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 02:17:00