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Titolo:
VEGF-A, VEGF-C, and VEGF-D in colorectal cancer progression
Autore:
George, ML; Tutton, MG; Janssen, F; Arnaout, A; Abulafi, AM; Eccles, SA; Swift, RI;
Indirizzi:
Inst Canc Res, Sect Canc Therapeut, Sutton SM2 5NG, Surrey, England Inst Canc Res Sutton Surrey England SM2 5NG tton SM2 5NG, Surrey, England Mayday Univ Hosp, Colorectal Unit, Croydon CR7 7YE, Surrey, England MaydayUniv Hosp Croydon Surrey England CR7 7YE CR7 7YE, Surrey, England Mayday Univ Hosp, Dept Histopathol, Croydon CR7 7YE, Surrey, England Mayday Univ Hosp Croydon Surrey England CR7 7YE CR7 7YE, Surrey, England
Titolo Testata:
NEOPLASIA
fascicolo: 5, volume: 3, anno: 2001,
pagine: 420 - 427
SICI:
1522-8002(200109/10)3:5<420:VVAVIC>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIAL GROWTH-FACTOR; LYMPH-NODE METASTASIS; ANGIOGENESIS IN-VIVO; FACTOR EXPRESSION; COLON-CANCER; TYROSINE KINASES; HUMAN TUMORS; RECEPTOR; PROGNOSIS; LIGAND;
Keywords:
angiogenesis; immunohistochemistry; staging; lymphatic; adenoma-carcinoma;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: George, ML Inst Canc Res, Sect Canc Therapeut, McElwain Bldg,15 Cotswold Rd, Sutton SM2 5NG, Surrey, England Inst Canc Res McElwain Bldg,15 Cotswold Rd Sutton Surrey England SM2 5NG
Citazione:
M.L. George et al., "VEGF-A, VEGF-C, and VEGF-D in colorectal cancer progression", NEOPLASIA, 3(5), 2001, pp. 420-427

Abstract

We aimed to assess the relationship of the angiogenic cytokines VEGF-A, VEGF-C, and VEGF-D and their receptors VEGFR-2 and VEGFR-3 in the adenoma-carcinoma sequence and in metastatic spread of colorectal cancer (CRC). mRNA expression levels were measured using semi-quantitative reverse transcription polymerase chain reaction in 70 CRC (35 with paired mucosae) and 20 adenomatous polyps. Immuohistochemistry and ELISA assessed protein expression. VEGF-D mRNA expression was significantly lower in both polyps and CRCs compared with normal mucosa (P=.0002 and .002, respectively), whereas VEGF-A andVEGF-C were significantly raised in CRCs (P=.006 and .004, respectively), but not polyps (P=.22 and P=.5, respectively). Receptor expression was similar in tumor tissue and normal mucosae. Tumors with lymph node metastases had significantly higher levels of VEGF-A compared with non-metastatic tumors (P=.043). There was no association between VEGF-C or VEGF-D and lymphaticspread. The decrease in VEGF-D occurring in polyps and carcinomas may allow the higher levels of VEGF-A and VEGF-C to bind more readily to the VEGF receptors, and produce the angiogenic switch required for tumor growth. Increased expression of VEGF-A within CRCs was associated with lymphatic metastases, and therefore, this member of the VEGF family may be the most important in determining metastatic spread.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 00:02:38