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Titolo:
The hemostatic system and angiogenesis in malignancy
Autore:
Wojtukiewicz, MZ; Sierko, E; Klement, P; Rak, J;
Indirizzi:
McMaster Univ, Hamilton Civ Hosp, Res Ctr, Dept Med, Hamilton, ON L8V 1C3,Canada McMaster Univ Hamilton ON Canada L8V 1C3 Med, Hamilton, ON L8V 1C3,Canada Med Acad Bialystok, Dept Oncol, Bialystok, Poland Med Acad Bialystok Bialystok Poland stok, Dept Oncol, Bialystok, Poland Univ Vet & Pharmaceut Sci Brno, Fac Vet, Brno, Czech Republic Univ Vet & Pharmaceut Sci Brno Brno Czech Republic Brno, Czech Republic
Titolo Testata:
NEOPLASIA
fascicolo: 5, volume: 3, anno: 2001,
pagine: 371 - 384
SICI:
1522-8002(200109/10)3:5<371:THSAAI>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIAL GROWTH-FACTOR; TISSUE FACTOR EXPRESSION; PLASMINOGEN-ACTIVATOR INHIBITOR-1; VASCULAR-PERMEABILITY FACTOR; MOLECULAR-WEIGHT KININOGEN; THROMBIN-INDUCED RELEASE; PLATELET-DERIVED MITOGENS; FACTOR PATHWAY INHIBITOR; METASTATIC TUMOR-CELLS; FACTOR UP-REGULATION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
255
Recensione:
Indirizzi per estratti:
Indirizzo: Rak, J McMaster Univ, Hamilton Civ Hosp, Res Ctr, Dept Med, 711 Concess St, Hamilton, ON L8V 1C3, Canada McMaster Univ 711 Concess St Hamilton ON Canada L8V 1C3 1C3, Canada
Citazione:
M.Z. Wojtukiewicz et al., "The hemostatic system and angiogenesis in malignancy", NEOPLASIA, 3(5), 2001, pp. 371-384

Abstract

Coagulopathy and angiogenesis are among the most consistent host responsesassociated with cancer. These two respective processes, hitherto viewed asdistinct, may in fact be functionally inseparable as blood coagulation andfibrinolysis, in their own right, influence tumor angiogenesis and therebycontribute to malignant growth. In addition, tumor angiogenesis appears tobe controlled through both standard and non-standard functions of such elements of the hemostatic system as tissue factor, thrombin, fibrin, plasminogen activators, plasminogen, and platelets. "Cryptic" domains can be released from hemostatic proteins through proteolytic cleavage, and act systemically as angiogenesis inhibitors (e.g., angiostatin, antiangiogenic antithrombin III aaATIII). Various components of the hemostatic system either promote or inhibit angiogenesis and likely act by changing the net angiogenic balance. However, their complex influences are far from being fully understood. Targeted pharmacological and/or genetic inhibition of pro-angiogenic activities of the hemostatic system and exploitation of endogenous angiogenesisinhibitors of the angiostatin and aaATIII variety are under study as prospective anti-cancer treatments.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/21 alle ore 03:13:46