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Titolo:
Novel observations with FDOPA-PET imaging after early nigrostriatal damage
Autore:
Yee, RE; Irwin, I; Milonas, C; Stout, DB; Huang, SC; Shoghi-Jadid, K; Satyamurthy, N; Delanney, LE; Togaski, DM; Farahani, KF; Delfani, K; Janson, AM; Phelps, ME; Langston, JW; Barrio, JR;
Indirizzi:
Univ Calif Los Angeles, Sch Med, Ctr Hlth Sci B2 086A, Dept Mol & Med Pharmacol, Los Angeles, CA 90095 USA Univ Calif Los Angeles Los Angeles CA USA90095 Los Angeles, CA 90095 USA Univ Calif Los Angeles, Sch Med, Dept Biomath, Los Angeles, CA 90024 USA Univ Calif Los Angeles Los Angeles CA USA 90024 Los Angeles, CA 90024 USA Parkinsons Inst, Sunnyvale, CA USA Parkinsons Inst Sunnyvale CA USAParkinsons Inst, Sunnyvale, CA USA Karolinska Inst, Dept Neurosci, Stockholm, Sweden Karolinska Inst Stockholm Sweden Inst, Dept Neurosci, Stockholm, Sweden Univ Calif Los Angeles, Sch Med, Dept Radiol Sci, Los Angeles, CA 90024 USA Univ Calif Los Angeles Los Angeles CA USA 90024 Los Angeles, CA 90024 USA
Titolo Testata:
MOVEMENT DISORDERS
fascicolo: 5, volume: 16, anno: 2001,
pagine: 838 - 848
SICI:
0885-3185(200109)16:5<838:NOWFIA>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; AMINO-ACID DECARBOXYLASE; NIGRAL CELL LOSS; PARKINSONS-DISEASE; SUBSTANTIA-NIGRA; IN-VIVO; DOPAMINERGIC-NEURONS; 6-FLUORO-L-DOPA KINETICS; ARBITRARY PARTICLES; SQUIRREL-MONKEY;
Keywords:
positron emission tomography; 6-[F-18]fluoro-L-DOPA; squirrel monkeys; Parkinson's diseased; stereology; optical fractionator;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
60
Recensione:
Indirizzi per estratti:
Indirizzo: Barrio, JR Univ Calif Los Angeles, Sch Med, Ctr Hlth Sci B2 086A, Dept Mol& Med Pharmacol, Los Angeles, CA 90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 , CA 90095 USA
Citazione:
R.E. Yee et al., "Novel observations with FDOPA-PET imaging after early nigrostriatal damage", MOVEMENT D, 16(5), 2001, pp. 838-848

Abstract

Striatal 6-[F-18]fluoro-L-DOPA (FDOPA) kinetic rate constants were measured by positron emission tomography (PET) in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated squirrel monkeys. After scanning, stereologicalcounts of dopaminergic neurons were done in substantia nigra. and dopamine(DA) and metabolite concentrations were determined in the caudate, putamen, and substantia nigra. Graded doses of MPTP produced animals with mild to moderate reductions (10-35%) in dopaminergic neurons, where the percent of cell loss was proportional to the amount of MPTP given. Striatal DA and metabolite concentrations were relatively unchanged in animals given 1.0 and 1.5 mg/kg of MPTP, but were significantly reduced after 2.0 mg/kg of MPTP. All animals injected with a single dose of MPTP showed no overt signs of parkinsonism. In contrast, DA and metabolite concentrations in the substantia nigra were significantly reduced for all MPTP-treated animals. Reduction ofdopaminergic indices in the substantia nigra did not parallel reductions in the striatum, indicating differential sensitivity of the nigrostriatal pathway to the neurotoxic effects of MPTP. The percent change in FDOPA uptake(Ki) and decarboyxlation (k(3)) after MPTP showed significant positive correlations to striatal DA levels, but not to the number of dopaminergic neurons. This suggests that FDOPA is a good index of striatal DA levels. (C) 2001 Movement Disorder Society.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 09:34:46