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Titolo:
Role of STAT3 and Pl 3-Kinase/Akt in mediating the survival actions of cytokines on sensory neurons
Autore:
Alonzi, T; Middleton, G; Wyatt, S; Buchman, V; Betz, UAK; Muller, W; Musiani, P; Poli, V; Davies, AM;
Indirizzi:
Univ Dundee, Wellcome Trust Bioctr, Sch Life Sci, Dundee DD1 5EH, ScotlandUniv Dundee Dundee Scotland DD1 5EH h Life Sci, Dundee DD1 5EH, Scotland Royal Dick Sch Vet Studies, Dept Preclin Vet Sci, Edinburgh EH9 1QH, Midlothian, Scotland Royal Dick Sch Vet Studies Edinburgh Midlothian Scotland EH9 1QH Scotland Univ Cologne, Inst Genet, D-5000 Cologne, Germany Univ Cologne Cologne Germany D-5000 Inst Genet, D-5000 Cologne, Germany Univ Chieti, Dept Oncol & Neurosci, Chieti, Italy Univ Chieti Chieti Italy v Chieti, Dept Oncol & Neurosci, Chieti, Italy
Titolo Testata:
MOLECULAR AND CELLULAR NEUROSCIENCE
fascicolo: 3, volume: 18, anno: 2001,
pagine: 270 - 282
SICI:
1044-7431(200109)18:3<270:ROSAP3>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
NERVE GROWTH-FACTOR; KINASE-DEPENDENT PATHWAY; KAPPA-B ACTIVATION; BCL-X-L; SYMPATHETIC NEURONS; PROTEIN-KINASE; PHOSPHATIDYLINOSITOL 3-KINASE; CELL-DEATH; CNTF RECEPTOR; TRANSCRIPTION FACTOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
68
Recensione:
Indirizzi per estratti:
Indirizzo: Alonzi, T IRCCS L Spallanzani, Gene Express Lab, Rome, Italy IRCCS L Spallanzani Rome Italy Gene Express Lab, Rome, Italy
Citazione:
T. Alonzi et al., "Role of STAT3 and Pl 3-Kinase/Akt in mediating the survival actions of cytokines on sensory neurons", MOL CELL NE, 18(3), 2001, pp. 270-282

Abstract

The binding of cytokines to the gp130 receptor activates the STAT3, MEK/MAPK, and PI3K/Akt signalling pathways. To assess the relative importance of these pathways in promoting the survival of cytokine-dependent neurons, we conditionally inactivated STAT3 in mice an inhibited MEK, PI3K, and Akt in cultured neurons using pharmacological reagents and by expressing specific inhibitory proteins. Inactivation of STAT3 enhanced the death of the cytokine-dependent sensory neurons of the nodose ganglion in vivo and substantially reduced the response of these neurons to CNTF and LIF in vitro. LY294002, an inhibitor of PI3K, but not PD98059, an inhibitor of MEK, markedly reduced the response of these neurons to CNTF, as did dominant-negative PI3K, dominant-negative Akt, and overexpression of Ruk(1) (a natural PI3K inhibitor). These results demonstrate that STAT3 and PI3K/Akt signalling play majorroles in mediating the survival response of neurons to cytokines.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 19:13:43