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Titolo:
Srg3, a mouse homolog of yeast SWI3, is essential for early embryogenesis and involved in brain development
Autore:
Kim, JK; Huh, SO; Choi, H; Lee, KS; Shin, D; Lee, C; Nam, JS; Kim, H; Chung, H; Lee, HW; Park, SD; Seong, RH;
Indirizzi:
Seoul Natl Univ, Inst Mol Biol & Genet, Seoul 151742, South Korea Seoul Natl Univ Seoul South Korea 151742 enet, Seoul 151742, South Korea Seoul Natl Univ, Sch Biol Sci, Seoul 151742, South Korea Seoul Natl Univ Seoul South Korea 151742 Sci, Seoul 151742, South Korea Hallym Univ, Coll Med, Inst Nat Med, Chunchon 200702, South Korea Hallym Univ Chunchon South Korea 200702 ed, Chunchon 200702, South Korea Hallym Univ, Coll Med, Dept Pharmacol, Chunchon 200702, South Korea HallymUniv Chunchon South Korea 200702 ol, Chunchon 200702, South Korea Chonnam Natl Univ, Hormone Res Ctr, Kwangju 500757, South Korea Chonnam Natl Univ Kwangju South Korea 500757 Kwangju 500757, South Korea Korea Univ, Coll Med, Dept Anat, Seoul 136705, South Korea Korea Univ Seoul South Korea 136705 Dept Anat, Seoul 136705, South Korea Korea Univ, Coll Med, Inst Human Genet, Seoul 136705, South Korea Korea Univ Seoul South Korea 136705 man Genet, Seoul 136705, South Korea Sung Kyun Kwan Univ, Sch Med, Suwon 440746, South Korea Sung Kyun Kwan Univ Suwon South Korea 440746 , Suwon 440746, South Korea
Titolo Testata:
MOLECULAR AND CELLULAR BIOLOGY
fascicolo: 22, volume: 21, anno: 2001,
pagine: 7787 - 7795
SICI:
0270-7306(200111)21:22<7787:SAMHOY>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHROMATIN-REMODELING COMPLEX; NEURAL-TUBE CLOSURE; SNF COMPLEX; TRANSCRIPTIONAL ACTIVATORS; DROSOPHILA-MELANOGASTER; MULTISUBUNIT COMPLEX; MARCKS DEFICIENCY; GENETIC-ANALYSIS; BRAHMA GENE; CELL-CYCLE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
64
Recensione:
Indirizzi per estratti:
Indirizzo: Seong, RH Seoul Natl Univ, Inst Mol Biol & Genet, San 56-1 Bldg 105, Seoul151742, South Korea Seoul Natl Univ San 56-1 Bldg 105 Seoul South Korea 151742 orea
Citazione:
J.K. Kim et al., "Srg3, a mouse homolog of yeast SWI3, is essential for early embryogenesis and involved in brain development", MOL CELL B, 21(22), 2001, pp. 7787-7795

Abstract

Srg3 (SWI3-related gene product) is a mouse homolog of yeast SWI3, Drosophila melanogaster MOIRA (also named MOR/BAP155), and human BAF155 and is known as a core subunit of SWI/SNF complex. This complex is involved in the chromatin remodeling required for the regulation of transcriptional processesassociated with development, cellular differentiation, and proliferation. We generated mice with a null mutation in the Srg3 locus to examine its function in vivo. Homozygous mutants develop in the early implantation stage but undergo rapid degeneration thereafter. An in vitro outgrowth study revealed that mutant blastocysts hatch, adhere, and form a layer of trophoblast giant cells, but the inner cell mass degenerates after prolonged culture. Interestingly, about 20% of heterozygous mutant embryos display defects in brain development with abnormal organization of the brain, a condition knownas exencephaly. Histological examination suggests that exencephaly is caused by the failure in neural fold elevation, resulting in severe brain malformation. Our findings demonstrate that Srg3 is essential for early embryogenesis and plays an important role in the brain development of mice.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/21 alle ore 03:22:09