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Titolo:
Development of the avian lymphatic system
Autore:
Wilting, J; Papoutsi, M; Othman-Hassan, K; Rodrigttez-Niedenfuhr, M; Prols, F; Tomarev, SI; Eichmann, A;
Indirizzi:
Univ Freiburg, Inst Anat, D-79104 Freiburg, Germany Univ Freiburg Freiburg Germany D-79104 t Anat, D-79104 Freiburg, Germany NEI, Mol & Dev Biol Lab, NIH, Bethesda, MD 20892 USA NEI Bethesda MD USA 20892 Mol & Dev Biol Lab, NIH, Bethesda, MD 20892 USA CNRS, Inst Embryol Cellulaire & Mol, Coll France, F-94736 Nogent Sur Marne, France CNRS Nogent Sur Marne France F-94736 e, F-94736 Nogent Sur Marne, France
Titolo Testata:
MICROSCOPY RESEARCH AND TECHNIQUE
fascicolo: 2, volume: 55, anno: 2001,
pagine: 81 - 91
SICI:
1059-910X(20011015)55:2<81:DOTALS>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIAL GROWTH-FACTOR; VEGF-C; CHORIOALLANTOIC MEMBRANE; EMBRYONIC-DEVELOPMENT; MONOCLONAL-ANTIBODY; CELLS; RECEPTOR; DIFFERENTIATION; EXPRESSION; QUAIL;
Keywords:
avian embryo; chorioallantoic membrane; lymphangiogenesis; lymphangioblast; endothelium; VEGF-C; VEGFR-3; Prox1; quail-chick chimera;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
60
Recensione:
Indirizzi per estratti:
Indirizzo: Wilting, J Univ Freiburg, Inst Anat, Albertstr 17, D-79104 Freiburg, Germany Univ Freiburg Albertstr 17 Freiburg Germany D-79104 g, Germany
Citazione:
J. Wilting et al., "Development of the avian lymphatic system", MICROSC RES, 55(2), 2001, pp. 81-91

Abstract

Recently, highly specific markers of the lymphatic endothelium have been found enabling us to reinvestigate the embryonic origin of the lymphatics. Here we present a review of our studies on the development of the lymphatic system in chick and quail embryos. We show that the lymphatic endothelium is derived from two sources: the embryonic lymph sacs and mesenchymal lymphangioblasts. Proliferation studies reveal a BrdU-labeling index of 11.5% of lymph sac endothelial cells by day 6.25, which drops to 3.5% by day 7. Lymphangioblasts are able to integrate into the lining of lymph sacs. Lymphaticendothelial cells express the vascular endothelial growth factor (VEGF) receptors-2 and -3. Their ligand, VEGF-C, is expressed almost ubiquitously inembryonic and fetal tissues. Elevated expression levels are found in the tunica media of large blood vessels, which usually serve as major routes forgrowing lymphatics. The homeobox gene, Prox1, is expressed in lymphatic but not in blood vascular endothelial cells throughout all stages examined, namely, in developing lymph sacs of day 6 embryos and in lymphatics at day 16. Experimental studies show the existence of lymphangioblasts in the mesoderm, a considerable time before the development of the lymph sacs. Lymphangioblasts migrate from the somites into the somatopleure and contribute to the lymphatics of the limbs. Our studies indicate that these lymphangioblasts already express Prox1. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 09:46:09