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Titolo:
The peritoneal microcirculation in peritoneal dialysis
Autore:
Rippe, B; Rosengren, BI; Venturoli, D;
Indirizzi:
Univ Lund Hosp, Dept Nephrol, S-21185 Lund, Sweden Univ Lund Hosp Lund Sweden S-21185 p, Dept Nephrol, S-21185 Lund, Sweden
Titolo Testata:
MICROCIRCULATION
fascicolo: 5, volume: 8, anno: 2001,
pagine: 303 - 320
SICI:
1073-9688(200110)8:5<303:TPMIPD>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOLECULAR-WEIGHT PROTEINS; CAPILLARY-PERMEABILITY; LYMPHATIC ABSORPTION; HYDROSTATIC-PRESSURE; CAPD PATIENTS; BLOOD-FLOW; ULTRAFILTRATION CAPACITY; REFLECTION COEFFICIENTS; COMPUTER-SIMULATIONS; INTERSTITIAL MATRIX;
Keywords:
capillary permeability; interstitium; lymphatics; macromolecules aquaporins; transport;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
100
Recensione:
Indirizzi per estratti:
Indirizzo: Rippe, B Univ Lund Hosp, Dept Nephrol, S-21185 Lund, Sweden Univ Lund Hosp Lund Sweden S-21185 ephrol, S-21185 Lund, Sweden
Citazione:
B. Rippe et al., "The peritoneal microcirculation in peritoneal dialysis", MICROCIRCUL, 8(5), 2001, pp. 303-320

Abstract

This paper deals with the peritoneal microcirculation and with peritoneal exchange occurring in peritoneal dialysis (PD). The capillary wall is a major barrier to solute and water exchange across the peritoneal membrane. There is a bimodal size-selectivity of solute transport between blood and the peritoneal cavity, through pores of radius similar to 40-50 Angstrom as well as through a very low number of large pores of radius similar to 250 Angstrom. Furthermore, during glucose-induced osmosis during PD, nearly 40% of the total osmotic water flow occurs through molecular water channels, termed "aquaporin-1. " This causes an inequality between 1-sigma and the sieving coefficient for small solutes, which is a key feature of the "three pore model" of peritoneal transport. The peritoneal interstitium, coupled in series with the capillary walls, markedly modifies small-solute transport and makes large-solute transport asymmetric. Thus, although severely restricted in the blood-to-peritoneal direction, the absorption of large solutes from the peritoneal cavity occurs at a high clearance rate (similar to 1mL/min), largely independent of molecular radius. True absorption of macromolecules to the blood via lymphatics, however, seems to be occurring at a rate of similar to0.2mL/min. Several controversial issues regarding transcapillary and transperitoneal exchange mechanisms are discussed in this paper.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 20:02:07