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Titolo:
Mapping of brain activation in response to pharmacological agents using fMRI in the rat
Autore:
Houston, GC; Papadakis, NG; Carpenter, TA; Hall, LD; Mukherjee, B; James, MF; Huang, CLH;
Indirizzi:
Univ Cambridge, Physiol Lab, Cambridge CB2 3EG, England Univ Cambridge Cambridge England CB2 3EG Lab, Cambridge CB2 3EG, England Univ Cambridge, Sch Clin, Herchel Smith Lab Med Chem, Cambridge CB2 2PZ, England Univ Cambridge Cambridge England CB2 2PZ hem, Cambridge CB2 2PZ, England SmithKline Beecham Pharmaceut, Neurosci Res, Harlow CM19 5AW, Essex, England SmithKline Beecham Pharmaceut Harlow Essex England CM19 5AW ssex, England
Titolo Testata:
MAGNETIC RESONANCE IMAGING
fascicolo: 7, volume: 19, anno: 2001,
pagine: 905 - 919
SICI:
0730-725X(200109)19:7<905:MOBAIR>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL BLOOD-FLOW; CHLORALOSE ANESTHETIZED RATS; CENTRAL NERVOUS-SYSTEM; HUMAN VISUAL-CORTEX; GLUCOSE-UTILIZATION; ALPHA-CHLORALOSE; FUNCTIONAL MRI; META-CHLOROPHENYLPIPERAZINE; SOMATOSENSORY STIMULATION; FOREPAW STIMULATION;
Keywords:
fMRI; MK-801; mCPP; autoradiography fMRI;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Huang, CLH Univ Cambridge, Physiol Lab, Downing St, Cambridge CB2 3EG, England Univ Cambridge Downing St Cambridge England CB2 3EG G, England
Citazione:
G.C. Houston et al., "Mapping of brain activation in response to pharmacological agents using fMRI in the rat", MAGN RES IM, 19(7), 2001, pp. 905-919

Abstract

Functional MRI (fMRI) was used to investigate the effects of psychotropic compound activity in the rat brain in vivo, The effects of dizocilpine (MK-801) an N-methyl-D-aspartate receptor antagonist and m-chlorophenylpiperazine (mCPP), a 5-HT2b/2c-receptor agonist on rat brain activity were investigated over a time interval of about 1 h and the results were compared to published glucose utilisation and cerebral blood flow data. Signal magnitude increases were observed predominantly in limbic regions following MK-801 administration (0.5 mg/kg i.v) whereas signal decreases were restricted to neocortical areas, a characteristic, time dependent pattern of regional changes evolved from the thalamic nuclei to cortical regions. In contrast, mCPP (25 mg/kg i.p) produced gradual signal intensity increases in limbic and motor regions with signal decreases restricted to the visual, parietal and motor cortices. The results from both compounds show remarkable similarity with autoradiographic measurements of cerebral blood flow and glucose uptake. These experiments suggest that the spatiotemporal capabilities of fMRI may be applied to the in vivo investigation of psychoactive compound activity with potential for clinical applications. (C) 2001 Elsevier Science Inc. Allrights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 01:22:25