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Titolo:
Overall survival and local recurrence of 406 completely resected stage IIIa-N2 non-small cell lung cancer patients: questionnaire survey of the JapanClinical Oncology Group to plan for clinical trials
Autore:
Ichinose, Y; Kato, H; Koike, T; Tsuchiya, R; Fujisawa, T; Shimizu, N; Watanabe, Y; Mitsudomi, T; Yoshimura, M;
Indirizzi:
Kyushu Natl Canc Ctr, Fukuoka, Japan Kyushu Natl Canc Ctr Fukuoka JapanKyushu Natl Canc Ctr, Fukuoka, Japan Tokyo Med Univ, Tokyo, Japan Tokyo Med Univ Tokyo JapanTokyo Med Univ, Tokyo, Japan Niigata Canc Ctr Hosp, Niigata, Japan Niigata Canc Ctr Hosp Niigata Japan igata Canc Ctr Hosp, Niigata, Japan Natl Canc Ctr Hosp, Tokyo, Japan Natl Canc Ctr Hosp Tokyo JapanNatl Canc Ctr Hosp, Tokyo, Japan Chiba Univ, Sch Med, Chiba 280, Japan Chiba Univ Chiba Japan 280Chiba Univ, Sch Med, Chiba 280, Japan Okayama Univ, Sch Med, Okayama 700, Japan Okayama Univ Okayama Japan 700Okayama Univ, Sch Med, Okayama 700, Japan Kanazawa Univ, Sch Med, Kanazawa, Ishikawa 920, Japan Kanazawa Univ Kanazawa Ishikawa Japan 920 , Kanazawa, Ishikawa 920, Japan Aichi Canc Ctr Hosp, Nagoya, Aichi 464, Japan Aichi Canc Ctr Hosp Nagoya Aichi Japan 464 Hosp, Nagoya, Aichi 464, Japan Hyogo Med Ctr Adults, Akashi, Hyogo, Japan Hyogo Med Ctr Adults Akashi Hyogo Japan Ctr Adults, Akashi, Hyogo, Japan
Titolo Testata:
LUNG CANCER
fascicolo: 1, volume: 34, anno: 2001,
pagine: 29 - 36
SICI:
0169-5002(200110)34:1<29:OSALRO>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYSTEMATIC MEDIASTINAL LYMPHADENECTOMY; PROGNOSTIC FACTORS; IMPACT;
Keywords:
local recurrence; non-small cell lung cancer; pathological stage IIIA-N2 disease; number of N2 stations; survival;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Ichinose, Y Kyushu Natl Canc Ctr, Fukuoka, Japan Kyushu Natl Canc Ctr Fukuoka Japan Canc Ctr, Fukuoka, Japan
Citazione:
Y. Ichinose et al., "Overall survival and local recurrence of 406 completely resected stage IIIa-N2 non-small cell lung cancer patients: questionnaire survey of the JapanClinical Oncology Group to plan for clinical trials", LUNG CANC, 34(1), 2001, pp. 29-36

Abstract

Background: the group of completely resected stage IIIA-N2 non-small cell lung cancer patients (NSCLC) is considered to be heterogenous in various aspects including survival and the recurrent pattern. In the present study, we attempted to clarify the factors which separate these patients into high and low risk groups based on the survival and local recurrence. Methods: a questionnaire survey on the survival and local recurrence of non-small celllung cancer patients with pathological stage IIIA-N2 disease who underwenta complete resection from January 1992 to December 1993 was performed by the Japan Clinical Oncology Group as of July 1999. The information on the survival of 406 patients and that of local recurrence in 332 of them was available. Results: the 5-year survival of the 406 patients was 31.0%. In a univariate analysis, the age, clinical and pathological T status, number of N2stations, pathological NI disease, operative modality and postoperative radiotherapy were all found to be important prognostic factors. Clinical N2 disease marginally influenced the survival (P=0.07). In a multivariate analysis of these variables including clinical N2 disease, the survival was significantly worse in the case of multiple N2 stations (hazard ratio=1.741), the presence of pathological NI disease (1.403), pathological T2 or 3 disease (1.399) and an age older than 65 (1.327). The rate of freedom from any local recurrence at the bronchial stump, or in the hilar, mediastinal or supraclavicular lymph nodes at 5 years was 64%. In a univariate analysis of thefreedom from local recurrence, the clinical N status, pathological T status, pathological N1 disease and number of N2 stations were all found to be important prognostic factors. A multivariate analysis revealed the freedom from local recurrence to be adversely influenced by multiple N2 stations (hazard ratio=2.05), and the presence of either clinical N1 or 2 (1.733) disease. The 5-year survival and the rate of freedom from local recurrence at 5 years were 43 and 75% in patients with a single N2 station and 17 and 48% in those with multiple N2 stations, respectively. Conclusions: the number ofN2 stations (single vs. multiple N2 stations) was found to be a useful prognostic factor, which can separate completely resected stage IIIA-N2 patients into high and low risk groups regarding both the overall survival and local recurrence. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

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Documento generato il 30/09/20 alle ore 08:38:08