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Titolo:
Thin-layer chromatographic separation of chiral drugs on molecularly imprinted chiral stationary phases
Autore:
Suedee, R; Srichana, T; Saelim, J; Thavonpibulbut, T;
Indirizzi:
Prince Songkla Univ, Fac Pharmaceut Sci, Dept Pharmaceut Chem, Songkhla 90110, Thailand Prince Songkla Univ Songkhla Thailand 90110 em, Songkhla 90110, Thailand
Titolo Testata:
JPC-JOURNAL OF PLANAR CHROMATOGRAPHY-MODERN TLC
fascicolo: 3, volume: 14, anno: 2001,
pagine: 194 - 198
SICI:
0933-4173(200105/06)14:3<194:TCSOCD>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYNTHETIC-POLYMERS; RECOGNITION; RESOLUTION; NAPROXEN; ABILITY;
Keywords:
TLC; molecularly imprinted polymer; enantiomers; beta-blockers; non-steroidal anti-inflammatory drugs (NSAID);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Suedee, R Prince Songkla Univ, Fac Pharmaceut Sci, Dept Pharmaceut Chem, Songkhla 90110, Thailand Prince Songkla Univ Songkhla Thailand 90110 la 90110, Thailand
Citazione:
R. Suedee et al., "Thin-layer chromatographic separation of chiral drugs on molecularly imprinted chiral stationary phases", J PL CHROM, 14(3), 2001, pp. 194-198

Abstract

This report describes the TLC separation of two classes of chiral drug, including beta -blocking drugs and non-steroidal antiinflammatory drugs (NSAID) on molecularly imprinted chiral stationary phases, in the same way as has been performed by HPLC. Several molecularly imprinted polymers (MIP) wereprepared using the enantiomers of either the beta -blocking drugs, R(+)-propranolol, R-(+)- or S-(-)-atenotol, or the NSAID, S-(+)-naproxen and S-(+)-ibuprofen, as print molecules. Three different functional monomers, ITA, MAA, and VPD were employed in the imprinting process. The polymers prepared in the presence of MAA or VPD could be coated as thin layers on glass supports, but not those prepared in the presence of ITA. The MIP of R-(+)propranolol, with 5% acetic acid in acetonitrile as mobile phase, resolved the racemate of propranolol into two spots, but tailing spots were obtained. The MIP prepared from S-(+)-naproxen, with 1% acetic acid in THF-heptane, 1 + 1,as mobile phase, resolved the racemate of ketoprofen into enantiomers, with a good separation factor (alpha = 5.2).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 21:55:54