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Titolo:
Composition of the extracellular matrix of the peritoneum
Autore:
Witz, CA; Montoya-Rodriguez, IA; Cho, S; Centonze, VE; Bonewald, LF; Schenken, RS;
Indirizzi:
Univ Texas, Hlth Sci Ctr, Div Reprod Endocrinol & Infertil, Dept Obstet & Gynecol, San Antonio, TX 78229 USA Univ Texas San Antonio TX USA 78229 & Gynecol, San Antonio, TX 78229 USA Univ Texas, Hlth Sci Ctr, Dept Struct & Cellular Biol, San Antonio, TX 78229 USA Univ Texas San Antonio TX USA 78229 lular Biol, San Antonio, TX 78229 USA Univ Texas, Hlth Sci Ctr, Dept Internal Med, San Antonio, TX 78229 USA Univ Texas San Antonio TX USA 78229 ternal Med, San Antonio, TX 78229 USA
Titolo Testata:
JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION
fascicolo: 5, volume: 8, anno: 2001,
pagine: 299 - 304
SICI:
1071-5576(200109/10)8:5<299:COTEMO>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
LAMININ ALPHA-5 CHAIN; MESOTHELIAL CELLS; BASEMENT-MEMBRANES; IV COLLAGEN; FIBRONECTIN; EXPRESSION; CARCINOMA; ADHESION; BINDING; MODEL;
Keywords:
peritoneum; collagen; fibronectin; laminin; endometriosis; cancer metastasis; confocal microscopy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Witz, CA Univ Texas, Hlth Sci Ctr, Div Reprod Endocrinol & Infertil, Dept Obstet & Gynecol, 7703 Floyd Curl Dr,Mail Code 7836, San Antonio, TX 78229 USA Univ Texas 7703 Floyd Curl Dr,Mail Code 7836 San Antonio TX USA 78229
Citazione:
C.A. Witz et al., "Composition of the extracellular matrix of the peritoneum", J SOC GYN I, 8(5), 2001, pp. 299-304

Abstract

OBJECTIVE: To localize the extracellular matrix proteins collagen I, collagen IV, fibronectin, and laminin in the peritoneal membrane. STUDY DESIGN: Peritoneal biopsies (n = 13) from the anterior abdominal wall and the uterine serosa (n = 3) were incubated with antibodies to collagenIV, laminin, collage I, and fibronectin. Specimens were examined using light and confocal laser scanning microscopy. RESULTS: All of the extracellular matrix (ECM) proteins were present immediately under the mesothelium. Collagen (Col) IV and laminin (LM) were seen in the smooth muscle of microvascular structures, in subendothelial basement membrane, and were present in a fascicular pattern in the peritoneal stroma. Collagen I was distributed diffusely in the peritoneal stroma. Fibronectin was also present in the subendothelial basement membrane. CONCLUSIONS: The resolution of the confocal microscope allowed for localization of extracellular matrix proteins in relation to the mesothelium. The presence of collagen IV, laminin, collagen I, and fibronectin under the mesothelium suggests that cells invading the peritoneum must have the ability to degrade and remodel this matrix. Copyright (C) 2001 by the Society for Gynecologic Investigation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 09:05:38