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Titolo:
LC determination of carbamazepine in murine brain
Autore:
Owen, A; Tettey, JN; Morgan, P; Pirmohamed, M; Park, BK;
Indirizzi:
Univ Liverpool, Dept Pharmacol & Therapeut, Ashton St Med Sch, Liverpool L69 3GE, Merseyside, England Univ Liverpool Liverpool Merseyside England L69 3GE , Merseyside, England Univ Strathclyde, Strathclyde Inst Biomed Sci, Glasgow G4 0NR, Lanark, Scotland Univ Strathclyde Glasgow Lanark Scotland G4 0NR G4 0NR, Lanark, Scotland Pfizer Global Res & Dev, Dept Drug Metab, Sandwich CT13 9NJ, Kent, EnglandPfizer Global Res & Dev Sandwich Kent England CT13 9NJ 9NJ, Kent, England
Titolo Testata:
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
fascicolo: 4, volume: 26, anno: 2001,
pagine: 573 - 577
SICI:
0731-7085(200111)26:4<573:LDOCIM>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
METABOLITE; EPILEPSY;
Keywords:
carbamazepine; RP-HPLC; brain; mouse;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
12
Recensione:
Indirizzi per estratti:
Indirizzo: Park, BK Univ Liverpool, Dept Pharmacol & Therapeut, Ashton St Med Sch, Liverpool L69 3GE, Merseyside, England Univ Liverpool Liverpool Merseyside England L69 3GE ide, England
Citazione:
A. Owen et al., "LC determination of carbamazepine in murine brain", J PHARM B, 26(4), 2001, pp. 573-577

Abstract

A reversed phase HPLC method for the determination of carbamazepine (CBZ) in the brain of adult mice is described. CBZ was recovered from murine brain by solvent-extraction with ethyl acetate and resolved from imipramine (internal standard) and brain endogenous material using a Lichrospher RP select B column with a linear gradient of acetonitrile (40 80 v/v, 25 min) in ammonium acetate buffer (25 mM, pH 4.0) with UV detection at 285 nm. The method is selective, reproducible and precise with a limit detection of 45 ng/ml and is suitable for the determination of CBZ in murine brain after intra-peritoneal administration. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 23:35:52