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Titolo:
First-derivative spectrophotometric and LC determination of nifedipine in Brij((R)) 96 based oil/water/oil multiple microemulsions on stability studies
Autore:
Castro, D; Moreno, MA; Lastres, JL;
Indirizzi:
Univ Complutense Madrid, Fac Pharm, Dept Pharm & Pharmaceut Technol, E-28040 Madrid, Spain Univ Complutense Madrid Madrid Spain E-28040 hnol, E-28040 Madrid, Spain
Titolo Testata:
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
fascicolo: 4, volume: 26, anno: 2001,
pagine: 563 - 572
SICI:
0731-7085(200111)26:4<563:FSALDO>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
LIQUID-CHROMATOGRAPHIC DETERMINATION; GAS-CHROMATOGRAPHY; HEALTHY-SUBJECTS; HUMAN-PLASMA; PHOTODECOMPOSITION; HYDROCHLORIDE; METABOLITES; EXTRACTION; KINETICS; TABLETS;
Keywords:
high performance liquid chromatography; derivative UV spectrophotometry; O/W/O multiple microemulsion; nifedipine; validation; stability studies;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Castro, D Univ Complutense Madrid, Fac Pharm, Dept Pharm & Pharmaceut Technol, E-28040 Madrid, Spain Univ Complutense Madrid Madrid Spain E-28040 040 Madrid, Spain
Citazione:
D. Castro et al., "First-derivative spectrophotometric and LC determination of nifedipine in Brij((R)) 96 based oil/water/oil multiple microemulsions on stability studies", J PHARM B, 26(4), 2001, pp. 563-572

Abstract

A first-derivative spectrophotometric (D-1(387)) method was developed for the determination of nifedipine in oil/water/oil (O/W/O) multiple microemulsions during stability studies. The UV first-derivative spectra were recorded over the wavelength range 200-600 nm (Delta lambda = 16). The derivativeprocedure was based on the linear relationship between nifedipine concentration and the first-derivative amplitude at 387 nm. This method was validated and compared with a liquid chromatography (LC) procedure used for the quantitative analysis of the drug. Both methods showed excellent precision and accuracy with values of 2.09 and 1.82%, respectively, for the LC method and of 1.53 and 1.64%, respectively. for the D-1(387) method. The established linearity range was 5 - 30 mug ml(-1) with r(2) values of 0.9980 and 0.9988 for LC and first-derivative procedures, respectively. Nifedipine recoveries from spiked placebos were >95% for both methods over the linear range analysed. These methods have been successfully used for determining of nifedipine content of multiple microemulsions during stability studies, since there was no interference with its decomposition products. (C) 2001 Elsevier Science B.V. All rights reserved.

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Documento generato il 19/01/20 alle ore 09:03:29