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Titolo:
Changes in the phospholipid composition of the arterial cell can result insevere atherosclerotic lesions
Autore:
Kummerow, FA; Cook, LS; Wasowicz, E; Jelen, H;
Indirizzi:
Univ Illinois, Burnsides Res Lab, Urbana, IL 61801 USA Univ Illinois Urbana IL USA 61801 Burnsides Res Lab, Urbana, IL 61801 USA Univ Illinois, Coll Med, Urbana, IL 61801 USA Univ Illinois Urbana IL USA61801 llinois, Coll Med, Urbana, IL 61801 USA Carle Fdn Hosp, Urbana, IL 61801 USA Carle Fdn Hosp Urbana IL USA 61801Carle Fdn Hosp, Urbana, IL 61801 USA
Titolo Testata:
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
fascicolo: 10, volume: 12, anno: 2001,
pagine: 602 - 607
SICI:
0955-2863(200110)12:10<602:CITPCO>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-DENSITY-LIPOPROTEIN; CORONARY HEART-DISEASE; SMOOTH-MUSCLE CELLS; INHIBITS 3 STEPS; ENDOTHELIAL-CELLS; OXIDIZED LDL; SARCOPLASMIC-RETICULUM; UP-REGULATION; FATTY STREAK; OXIDATION;
Keywords:
oxysterols; sphingomyelin; calcium; stenosis; arterial bifurcations; coronary heart disease;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Kummerow, FA Univ Illinois, Burnsides Res Lab, 1208 W Pennsylvania Ave, Urbana, IL 61801 USA Univ Illinois 1208 W Pennsylvania Ave Urbana IL USA 61801 USA
Citazione:
F.A. Kummerow et al., "Changes in the phospholipid composition of the arterial cell can result insevere atherosclerotic lesions", J NUTR BIOC, 12(10), 2001, pp. 602-607

Abstract

The oxysterol concentration in the plasma and the phospholipid compositionof vascular tissue obtained by coronary artery bypass grafting (CABG) werecompared with plasma and vascular tissue from age and sex matched controls. The Plasma from CABG patients had a higher concentration of oxysterols than was present in the controls. Human endothelial cells were cultured for 72 hours in a medium containing plasma obtained from CABG patients, from controls or from the same controls to which 5 oxysterols were added to make the total oxysterol level equivalent to that in the CABG plasma and then pulsed with calcium (Ca-45(2+)) for one fir. A significantly higher influx of Ca-45(2+) was noted in the endothelial cells cultured in the plasma obtainedfrom CABG patients and from the controls with 5 added oxysterols, but not in those cultured without added oxysterols indicating that oxysterols increased calcium influx into endothelial cells. A phospholipid analysis indicated that the arterial tissue from CABG patients had 48.2% sphingomyelin in its phospholipid fraction compared to 10% in arterial tissue from umbilical cords. The saphenous vein obtained during CABG surgery from the same patient had only 24% sphingomyelin in its phospholipid fraction and unlike the coronary arteries had no atherosclerotic lesions. The higher level of oxysterol in the plasma of patients suffering from severe atherosclerosis could increase the concentration of sphingomyelin in the arterial cell membrane andthereby increase calcium influx required for producing the calcific type VII lesions in the coronary arteries. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 04:26:44