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Titolo:
An in vivo model for investigating bilateral synaptic plasticity across CA3/CA1 synapses in guinea pig dorsal hippocampus
Autore:
Chirwa, S; Mack, J; Park, R; Dennis, K; Aduonum, A;
Indirizzi:
Meharry Med Coll, Nashville, TN 37208 USA Meharry Med Coll Nashville TN USA 37208 Med Coll, Nashville, TN 37208 USA
Titolo Testata:
JOURNAL OF NEUROSCIENCE METHODS
fascicolo: 1-2, volume: 110, anno: 2001,
pagine: 25 - 30
SICI:
0165-0270(20010930)110:1-2<25:AIVMFI>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; RABBIT FOLLOWING STIMULATION; CURRENT-SOURCE DENSITY; LASTING POTENTIATION; PERFORANT PATH; COMMISSURAL AFFERENTS; RAT HIPPOCAMPUS; DENTATE AREA; CA1 NEURONS; TRANSMISSION;
Keywords:
bilateral LTP; CA1; CA3; guinea pig; hippocampus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Chirwa, S Meharry Med Coll, 1005 DB Todd Blvd, Nashville, TN 37208 USA Meharry Med Coll 1005 DB Todd Blvd Nashville TN USA 37208 08 USA
Citazione:
S. Chirwa et al., "An in vivo model for investigating bilateral synaptic plasticity across CA3/CA1 synapses in guinea pig dorsal hippocampus", J NEUROSC M, 110(1-2), 2001, pp. 25-30

Abstract

A method is described for concurrent investigation of long-term potentiation (LTP) in the left and right CA1 synapses in dorsal hippocampi in guinea pig in vivo. Briefly, animals are anesthetized with urethane, and small access holes are made in the skull through which electrodes are lowered to stimulate the left CA3 and record from both CA1 regions. Using this animal model, we have found that LTP is produced in both CA1 regions, following conditioning stimulation to the left CA3. However, in some animals LTP occurred in the left CA1 without concomitant synaptic potentiation in the contralateral CA1. We also observed that in some experiments synaptic potentiation inthe contralateral CA1, when present, decayed to baseline levels even though LTP persisted in the ipsilateral CA1. To conclude, our data on bilateral LTP demonstrates findings that are best addressed in vivo. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 12:08:20