Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Cutaneous vasoconstriction contributes to hyperthermia induced by 3,4-methylenedioxymethamphetamine (Ecstasy) in conscious rabbits
Autore:
Pedersen, NP; Blessing, WW;
Indirizzi:
Flinders Univ S Australia, Dept Med, Ctr Neurosci, Bedford Pk, SA 5042, Australia Flinders Univ S Australia Bedford Pk SA Australia 5042 SA 5042, Australia Flinders Univ S Australia, Dept Physiol, Ctr Neurosci, Bedford Pk, SA 5042, Australia Flinders Univ S Australia Bedford Pk SA Australia 5042 SA 5042, Australia
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 21, volume: 21, anno: 2001,
pagine: 8648 - 8654
SICI:
0270-6474(20011101)21:21<8648:CVCTHI>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
MDMA ECSTASY; THERMOREGULATORY RESPONSES; AMBIENT-TEMPERATURE; 5-HT2A RECEPTOR; HEALTHY HUMANS; BLOOD-FLOW; RAT; NEUROTOXICITY; PHARMACOLOGY; PRETREATMENT;
Keywords:
MDMA; ecstasy; temperature regulation; skin blood flow; heat loss; serotonin; 5-HT; hyperthermia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Blessing, WW Flinders Univ S Australia, Dept Med, Ctr Neurosci, Bedford Pk, SA 5042, Australia Flinders Univ S Australia Bedford Pk SA Australia 5042 ralia
Citazione:
N.P. Pedersen e W.W. Blessing, "Cutaneous vasoconstriction contributes to hyperthermia induced by 3,4-methylenedioxymethamphetamine (Ecstasy) in conscious rabbits", J NEUROSC, 21(21), 2001, pp. 8648-8654

Abstract

3,4-Methylenedioxymethamphetamine (MDMA; "Ecstasy") increases body temperature. This process could be associated with increased cutaneous blood flow,as normally occurs with exercise-induced hyperthermia. Alternatively, an MDMA-induced fall in cutaneous blood flow could contribute to the hyperthermia by diminishing normal heat transfer from the body to the environment. Weinvestigated these possibilities by administering MDMA (1.5-6 mg/kg, i.v.)to conscious freely moving rabbits, determining effects on body temperature, cutaneous blood flow (measured by a Doppler ultrasonic probe that was chronically implanted around the ear pinna artery), and other cardiovascular parameters. MDMA caused a dose-dependent increase in body temperature (from38.3 +/- 0.3 to 41.2 +/- 0.4 degreesC after 6 mg/kg; p < 0.01; n = 5), preceded and accompanied by a dose-dependent cutaneous vasoconstriction (from 29 +/- 6 to 5 +/- 1 cm/sec after 6 mg/kg; p < 0.01; n = 5). MDMA (3 mg/kg) did not change blood flow to the mesenteric vascular bed. Prior unilateral cervical sympathectomy reduced the increase in body temperature elicited byMDMA (6 mg/kg) from 2.0 +/- 0.2 to 1.3 +/- 0.2 degreesC (p < 0.01; n = 5). On the denervated side, ear pinna blood flow after MDMA injection was 13 +/- 3 cm/sec, compared with 3 +/- 1 cm/sec on the sympathetically intact side ( p < 0.05; n = 5). Thus, sympathetically mediated cutaneous vasoconstriction is one mechanism whereby MDMA causes hyperthermia. Reversal of cutaneous vasoconstriction by appropriate pharmacological means could be of therapeutic benefit in humans suffering from life-threatening hyperthermia induced by MDMA.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 13:45:53