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Titolo:
Microcircuits for night vision in mouse retina
Autore:
Tsukamoto, Y; Morigiwa, K; Ueda, M; Sterling, P;
Indirizzi:
Hyogo Med Univ, Dept Biol, Nishinomiya, Hyogo 6638501, Japan Hyogo Med Univ Nishinomiya Hyogo Japan 6638501 miya, Hyogo 6638501, Japan Osaka Univ, Grad Sch Med, Dept Physiol & Biosignaling, Suita, Osaka 5650871, Japan Osaka Univ Suita Osaka Japan 5650871 gnaling, Suita, Osaka 5650871, Japan Univ Penn, Dept Neurosci, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 Neurosci, Philadelphia, PA 19104 USA
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 21, volume: 21, anno: 2001,
pagine: 8616 - 8623
SICI:
0270-6474(20011101)21:21<8616:MFNVIM>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONE BIPOLAR CELLS; INNER PLEXIFORM LAYER; AII-AMACRINE CELLS; CAT RETINA; RABBIT RETINA; ROD PHOTORECEPTORS; MAMMALIAN RETINA; RAT RETINA; ALTERNATIVE PATHWAY; GANGLION-CELLS;
Keywords:
mouse retina; microcircuitry; rod circuits; bipolar cells; gap junctions; electron microscopy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Tsukamoto, Y Hyogo Med Univ, Dept Biol, 1-1 Mukogawa, Nishinomiya, Hyogo 6638501, Japan Hyogo Med Univ 1-1 Mukogawa Nishinomiya Hyogo Japan 6638501 n
Citazione:
Y. Tsukamoto et al., "Microcircuits for night vision in mouse retina", J NEUROSC, 21(21), 2001, pp. 8616-8623

Abstract

Because the mouse retina has become an important model system, we have begun to identify its specific neuron types and their synaptic connections. Here, based on electron micrographs of serial sections, we report that the wild-type mouse retina expresses the standard rod pathways known in other mammals: (1) rod --> cone (via gap junctions) to inject rod signals into the cone bipolar circuit; and (2) rod --> rod bipolar --> All amacrine --> cone bipolar --> ganglion cell. The mouse also expresses another rod circuit: a bipolar cell with cone input also receives rod input at symmetrical contacts that express ionotropic glutamate receptors (Hack et al., 1999, 2001). Weshow that this rod-cone bipolar cell sends an axon to the outer (OFF) strata of the inner plexiform layer to form ribbon synapses with ganglion and amacrine cells. This rod-cone bipolar cell receives direct contacts from only 20% of all rod terminals. However, we also found that rod terminals form gap junctions with each other and thus establish partial syncytia that could pool rod signals for direct chemical transmission to the OFF bipolar cell. This third rod pathway probably explains the rod responses that persist in OFF ganglion cells after the well known rod pathways are blocked (Soucy et al., 1998).

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Documento generato il 30/11/20 alle ore 16:51:22