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Titolo:
Functionally independent columns of rat somatosensory barrel cortex revealed with voltage-sensitive dye imaging
Autore:
Petersen, CCH; Sakmann, B;
Indirizzi:
Max Planck Inst Med Res, Dept Cell Physiol, D-69120 Heidelberg, Germany Max Planck Inst Med Res Heidelberg Germany D-69120 0 Heidelberg, Germany
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 21, volume: 21, anno: 2001,
pagine: 8435 - 8446
SICI:
0270-6474(20011101)21:21<8435:FICORS>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEDIAL NUCLEUS VPM; CORTICAL PLASTICITY; SYNAPTIC PLASTICITY; RECEPTIVE-FIELDS; CEREBRAL-CORTEX; SMI CORTEX; LAYER-IV; VIBRISSA; NEURONS; MOUSE;
Keywords:
neocortex; somatosensory cortex; barrel cortex; imaging; voltage-sensitive dye; plasticity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Petersen, CCH Max Planck Inst Med Res, Dept Cell Physiol, Jahnstr 29, D-69120 Heidelberg, Germany Max Planck Inst Med Res Jahnstr 29 Heidelberg Germany D-69120
Citazione:
C.C.H. Petersen e B. Sakmann, "Functionally independent columns of rat somatosensory barrel cortex revealed with voltage-sensitive dye imaging", J NEUROSC, 21(21), 2001, pp. 8435-8446

Abstract

Whisker movement is somatotopically represented in rodent neocortex by electrical activity in clearly defined barrels, which can be visualized in living brain slices. The functional architecture of this part of the cortex can thus be mapped in vitro with respect to its physiological input and compared with its anatomical architecture. The spatial extent of excitation was measured at high temporal resolution by imaging optical signals from voltage-sensitive dye evoked by stimulation of individual barrels in layer 4. Theoptical signals correlated closely with subthreshold EPSPs recorded simultaneously from excitatory neurons in layer 4 and layer 2/3, respectively. Excitation was initially (<2 msec) limited to the stimulated barrel and subsequently (>3 msec) spread in a columnar manner into layer 2/3 and then subsided in both layers after similar to 50 msec. The lateral extent of the response was limited to the cortical column defined structurally by the barrel in layer 4. Two experimental interventions increased the spread of excitation. First, blocking GABA(A) receptor-mediated synaptic inhibition caused excitation to spread laterally throughout wide regions of layer 2/3 and layer5 but not into neighboring barrels, suggesting that the local excitatory connections within layer 4 are restricted to single barrels and that inhibitory neurons control spread in supragranular and infragranular layers. Second, NMDA receptor-dependent increase of the spread of excitation was inducedby pairing repetitive stimulation of a barrel column with coincident stimulation of layer 2/3 in a neighboring column. Such plasticity in the spatialextent of excitation in a barrel column could underlie changes in corticalmap structure induced by alterations of sensory experience.

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Documento generato il 05/04/20 alle ore 03:38:10