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Titolo:
Neuronal glutamate transporters limit activation of NMDA receptors by neurotransmitter spillover on CA1 pyramidal cells
Autore:
Diamond, JS;
Indirizzi:
NINCDS, Synapt Physiol Unit, NIH, Bethesda, MD 20892 USA NINCDS Bethesda MD USA 20892 pt Physiol Unit, NIH, Bethesda, MD 20892 USA
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 21, volume: 21, anno: 2001,
pagine: 8328 - 8338
SICI:
0270-6474(20011101)21:21<8328:NGTLAO>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYNAPTICALLY RELEASED GLUTAMATE; CEREBELLAR GRANULE CELLS; BERGMANN GLIAL-CELLS; MOSSY FIBER SYNAPSES; TIME-COURSE; EXTRASYNAPTIC GLUTAMATE; RAT HIPPOCAMPUS; SILENT SYNAPSES; DENDRITIC MORPHOLOGY; PARALLEL FIBER;
Keywords:
spillover; glutamate transporters; diffusion; Monte Carlo simulation; hippocampus; NMDA receptor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
64
Recensione:
Indirizzi per estratti:
Indirizzo: Diamond, JS NINCDS, Synapt Physiol Unit, NIH, Bldg 36,Room 2C09,36 ConventDr, Bethesda, MD 20892 USA NINCDS Bldg 36,Room 2C09,36 Convent Dr BethesdaMD USA 20892 A
Citazione:
J.S. Diamond, "Neuronal glutamate transporters limit activation of NMDA receptors by neurotransmitter spillover on CA1 pyramidal cells", J NEUROSC, 21(21), 2001, pp. 8328-8338

Abstract

Glutamate released at synapses in the CA1 region of the hippocampus escapes the synaptic cleft and activates extrasynaptic targets; it also may "spill over" into neighboring synapses and activate receptors there. Glutamate transporters in glial membranes restrict extrasynaptic diffusion, but it is unclear whether neuronal glutamate transporters also limit transmitter diffusion and receptor activation by spillover. I examined the effects of a low-affinity competitive NMDA receptor antagonist on EPSCs in acute hippocampal slices to distinguish receptors activated within active synapses from those activated by spillover. Glutamate spillover is observed between Schaffercollateral fiber synapses onto CA1 pyramidal cells only when transporters in the postsynaptic neuron are inhibited. Because glutamate transporters operate most effectively at negative membrane potentials, these results suggest that activation of NMDA receptors by spillover may depend on postsynaptic activity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 17:39:01